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Rabbit Polyclonal Cleaved-Integrin alpha7 LC (E959) antibody (STJ90090)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:40000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-Integrin alpha7 LC (E959) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ITGA7 antibody, UNQ406/PRO768 antibody,|alpha 7 antibody|FLJ25220 antibody|Integrin alpha 7 antibody|Integrin alpha 7 chain antibody|Integrin alpha 7 heavy chain antibody|Integrin alpha 7 light chain antibody|Integrin alpha-7 70 kDa form antibody|ITA7_HUMAN antibody|ITGA 7 antibody|Itga7 antibody|Anti-ITGA7 antibody (ab75224)
SCBT cat No: sc-81807|sc-27710|sc-50431|sc-27706|
Cleaved-Integrin alpha7 LC (E959) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-Integrin alpha7 LC (E959) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin alpha7 LC protein resulting from cleavage adjacent to E959.
Synthesized peptide derived from Cleaved-Integrin alpha7 LC (E959) at AA range 910-990
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:40000;
|Molecular weight|| |
Cleaved-Integrin alpha7 LC (E959) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-Integrin alpha7 LC (E959) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Integrin alpha-7 antibody
|Protein names|| |
|Protein function|| |
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
|Protein tissue specificity|| |
Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle.
|Involvement in disease|| |
Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI) [MIM:613204]: A form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the integrin alpha chain family. / Contains 7 FG-GAP repeats.
|Protein post-translational modifications|| |
ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes. / A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin.
|Protein cellular localization|| |
Membrane; Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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