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Rabbit Polyclonal Cleaved-KLK8 (V33) antibody (STJ90055)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-KLK8 (V33) Polyclonal Antibody.
Check alternative names for the antibodyExpand
KLK8 antibody, NRPN antibody, PRSS19 antibody, TADG14 antibody, UNQ283/PRO322 antibody,|Brain serine protease 1 antibody|Kallikrein-8 antibody|Kallikrein8 antibody|KLK 8 antibody|Klk8 antibody|KLK8 protein type 1 antibody|KLK8 protein type 2 antibody|KLK8_HUMAN antibody|Neuropsin antibody|neuropsin type 1 antibody|Neuropsin type 1, included antibody|Neuropsin type 2 antibody|Neuropsin type 2, included antibody|Neuropsin, mouse, homolog of antibody|NP antibody|NRPN antibody|Ovasin antibody|PRO322 antibody|Protease serine 19 antibody|PRSS 19 antibody|PRSS19 antibody|Serine protease 19 antibody|Serine protease kallikrein antibody|Serine protease kallikrein/ovasin/neuropsin antibody|Serine protease TADG 14 antibody|Serine protease TADG-14 antibody|Serine protease TADG14 antibody|TADG 14 antibody|TADG14 antibody|Tumor associated differentially expressed gene 14 antibody|Tumor associated differentially expressed gene 14 protein antibody|Tumor-associated differentially expressed gene 14 protein antibody|UNQ283 antibody|Anti-Kallikrein 8 antibody [EPR5752(2)] (ab150395)
SCBT cat No: sc-292340|sc-292341|
Cleaved-KLK8 (V33) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-KLK8 (V33) Polyclonal Antibody detects endogenous levels of fragment of activated KLK8 protein resulting from cleavage adjacent to V33.
Synthesized peptide derived from Cleaved-KLK8 (V33) at AA range 30-110
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
Cleaved-KLK8 (V33) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-KLK8 (V33) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Kallikrein-8 antibody, hK8 antibody, Neuropsin antibody, NP antibody, Ovasin antibody, Serine protease 19 antibody, Serine protease TADG-14 antibody, Tumor-associated differentially expressed gene 14 protein antibody
|Protein names|| |
Kallikrein-8 , hK8 , Neuropsin , NP , Ovasin , Serine protease 19 , Serine protease TADG-14 , Tumor-associated differentially expressed gene 14 protein
|Protein function|| |
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. / Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys. / Inhibited by a range of serine protease inhibitors including antipain, aprotinin, leupeptin, benzamidine and soybean trypsin inhibitor. / 0.07 mM for Pro-Phe-Arg-MCA / 0.07 mM for Z-Val-Val-Arg-MCA / 0.07 mM for Boc-Val-Pro-Arg-MCA / 0.10 mM for Boc-Leu-Lys-Arg-MCA / 0.10 mM for Boc-Val-Leu-Lys-MCA / 0.07 mM for Boc-Phe-Ser-Arg-MCA / 7.1 µmol/min/mg enzyme toward Pro-Phe-Arg-MCA / 5.4 µmol/min/mg enzyme toward Z-Val-Val-Arg-MCA / 3.9 µmol/min/mg enzyme toward Boc-Val-Pro-Arg-MCA / 2.6 µmol/min/mg enzyme toward Boc-Leu-Lys-Arg-MCA / 1.9 µmol/min/mg enzyme toward Boc-Val-Leu-Lys-MCA / 1.6 µmol/min/mg enzyme toward Boc-Phe-Ser-Arg-MCA / Optimum pH is 8.5. Active from pH 7-10.
|Protein tissue specificity|| |
Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes.
|Protein sequence and domain|| |
Belongs to the peptidase S1 family. Kallikrein subfamily. / Contains 1 peptidase S1 domain.
|Protein cellular localization|| |
Secreted / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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