Rabbit Polyclonal Cleaved-MMP-12 (G106) antibody (STJ90059)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-MMP-12 (G106) antibody (STJ90059)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cleaved-MMP-12 (G106) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

MMP12 antibody, HME antibody,|EC 3.4.24.65 antibody|HME antibody|Macrophage elastase antibody|Macrophage metalloelastase antibody|Macrophage metaloelastase antibody|Matrix metallopeptidase 12 (macrophage elastase) antibody|Matrix metalloprotease 12 antibody|Matrix metalloproteinase-12 antibody|ME antibody|MGC138506 antibody|MME antibody|MMP 12 antibody|MMP-12 antibody|Mmp12 antibody|MMP12_HUMAN antibody|Anti-MMP12 antibody [EP1261Y] (ab52897)
SCBT cat No: sc-30072|sc-390284|sc-12361|sc-8839|

 

Name

Cleaved-MMP-12 (G106) Polyclonal Antibody

Catalogue No.

STJ90059

Reactivity

Human

Specificity

Cleaved-MMP-12 (G106) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-12 protein resulting from cleavage adjacent to G106.

Immunogen

Synthesized peptide derived from Cleaved-MMP-12 (G106) at AA range 60-140

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

42 kDa

Formulation

Cleaved-MMP-12 (G106) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-MMP-12 (G106) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Macrophage metalloelastase antibody, MME antibody, Macrophage elastase antibody, ME antibody, hME antibody, Matrix metalloproteinase-12 antibody, MMP-12 antibody

Database links

Human UniProt/Swiss-Prot:P39900;Mouse UniPort/Swiss-Prot: P34960;Rat UniProt/Swiss-Port: Q63341;Human Entrez Gene: 4321;Mouse Entrez Gene: 17381;Rat Entrez Gene: Rn.33193

Protein names

Macrophage metalloelastase , MME , Macrophage elastase , ME , hME , Matrix metalloproteinase-12 , MMP-12

Protein function

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1′ site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. / Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-, -Leu-15 and 16-Tyr-, -Leu-17 in the B chain of insulin. / Ca2+ / Zn2+

Protein tissue specificity

Found in alveolar macrophages but not in peripheral blood monocytes.

Protein sequence and domain

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. / Belongs to the peptidase M10A family. / Contains 4 hemopexin repeats.

Protein cellular localization

Secreted > extracellular space > extracellular matrix

Research area

All research areas>Synthesis and Degradation>MMP
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize Cleaved-MMP-12 (G106) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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