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Rabbit Polyclonal Cleaved-MMP-12 (G106) antibody (STJ90059)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-MMP-12 (G106) Polyclonal Antibody.
Check alternative names for the antibodyExpand
MMP12 antibody, HME antibody,|EC 184.108.40.206 antibody|HME antibody|Macrophage elastase antibody|Macrophage metalloelastase antibody|Macrophage metaloelastase antibody|Matrix metallopeptidase 12 (macrophage elastase) antibody|Matrix metalloprotease 12 antibody|Matrix metalloproteinase-12 antibody|ME antibody|MGC138506 antibody|MME antibody|MMP 12 antibody|MMP-12 antibody|Mmp12 antibody|MMP12_HUMAN antibody|Anti-MMP12 antibody [EP1261Y] (ab52897)
SCBT cat No: sc-30072|sc-390284|sc-12361|sc-8839|
Cleaved-MMP-12 (G106) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-MMP-12 (G106) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-12 protein resulting from cleavage adjacent to G106.
Synthesized peptide derived from Cleaved-MMP-12 (G106) at AA range 60-140
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Cleaved-MMP-12 (G106) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-MMP-12 (G106) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Macrophage metalloelastase antibody, MME antibody, Macrophage elastase antibody, ME antibody, hME antibody, Matrix metalloproteinase-12 antibody, MMP-12 antibody
|Protein names|| |
Macrophage metalloelastase , MME , Macrophage elastase , ME , hME , Matrix metalloproteinase-12 , MMP-12
|Protein function|| |
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1′ site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. / Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-, -Leu-15 and 16-Tyr-, -Leu-17 in the B chain of insulin. / Ca2+ / Zn2+
|Protein tissue specificity|| |
Found in alveolar macrophages but not in peripheral blood monocytes.
|Protein sequence and domain|| |
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. / Belongs to the peptidase M10A family. / Contains 4 hemopexin repeats.
|Protein cellular localization|| |
Secreted > extracellular space > extracellular matrix
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St John’s Laboratory Ltd.
|Product type|| |
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