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Rabbit Polyclonal Cleaved-MMP-14 (Y112) antibody (STJ90060)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-MMP-14 (Y112) Polyclonal Antibody.
Check alternative names for the antibodyExpand
MMP14 antibody,|Matrix metallopeptidase 14 (membrane inserted) antibody|Matrix metalloproteinase 14 antibody|Matrix metalloproteinase-14 antibody|Membrane type 1 matrix metalloproteinase antibody|Membrane type 1 metalloprotease antibody|Membrane type matrix metalloproteinase 1 antibody|Membrane-type matrix metalloproteinase 1 antibody|Membrane-type-1 matrix metalloproteinase antibody|MMP 14 antibody|MMP X1 antibody|MMP-14 antibody|MMP-X1 antibody|Mmp14 antibody|MMP14_HUMAN antibody|MMPX1 antibody|MT MMP 1 antibody|MT-MMP 1 antibody|MT1 MMP antibody|MT1-MMP antibody|MT1MMP antibody|MTMMP 1 antibody|MTMMP1 antibody|Anti-MMP14 antibody [EP1264Y] (ab51074)
SCBT cat No: sc-377097|sc-373908|sc-30074|sc-12367|sc-101451|sc-12366|
Cleaved-MMP-14 (Y112) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Cleaved-MMP-14 (Y112) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-14 protein resulting from cleavage adjacent to Y112.
Synthesized peptide derived from Cleaved-MMP-14 (Y112) at AA range 70-150
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Cleaved-MMP-14 (Y112) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-MMP-14 (Y112) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Matrix metalloproteinase-14 antibody, MMP-14 antibody, MMP-X1 antibody, Membrane-type matrix metalloproteinase 1 antibody, MT-MMP 1 antibody, MTMMP1 antibody, Membrane-type-1 matrix metalloproteinase antibody, MT1-MMP antibody, MT1MMP antibody
|Protein names|| |
Matrix metalloproteinase-14 , MMP-14 , MMP-X1 , Membrane-type matrix metalloproteinase 1 , MT-MMP 1 , MTMMP1 , Membrane-type-1 matrix metalloproteinase , MT1-MMP , MT1MMP
|Protein function|| |
Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. / Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-, -Leu-38. Other bonds hydrolyzed include 35-Gly-, -Ile-36 in the propeptide of collagenase 3, and 341-Asn-, -Phe-342, 441-Asp-, -Leu-442 and 354-Gln-, -Thr-355 in the aggrecan interglobular domain. / Zn2+ / Ca2+
|Protein tissue specificity|| |
Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
|Involvement in disease|| |
Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. / Belongs to the peptidase M10A family. / Contains 4 hemopexin repeats.
|Protein post-translational modifications|| |
The precursor is cleaved by a furin endopeptidase. / Tyrosine phosphorylated by PKDCC/VLK.
|Protein cellular localization|| |
Membrane / Melanosome / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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