Rabbit Polyclonal Cleaved-MMP-14 (Y112) antibody (STJ90060)

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Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-MMP-14 (Y112) antibody (STJ90060)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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MMP14 antibody,|Matrix metallopeptidase 14 (membrane inserted) antibody|Matrix metalloproteinase 14 antibody|Matrix metalloproteinase-14 antibody|Membrane type 1 matrix metalloproteinase antibody|Membrane type 1 metalloprotease antibody|Membrane type matrix metalloproteinase 1 antibody|Membrane-type matrix metalloproteinase 1 antibody|Membrane-type-1 matrix metalloproteinase antibody|MMP 14 antibody|MMP X1 antibody|MMP-14 antibody|MMP-X1 antibody|Mmp14 antibody|MMP14_HUMAN antibody|MMPX1 antibody|MT MMP 1 antibody|MT-MMP 1 antibody|MT1 MMP antibody|MT1-MMP antibody|MT1MMP antibody|MTMMP 1 antibody|MTMMP1 antibody|Anti-MMP14 antibody [EP1264Y] (ab51074)
SCBT cat No: sc-377097|sc-373908|sc-30074|sc-12367|sc-101451|sc-12366|

 

Name

Cleaved-MMP-14 (Y112) Polyclonal Antibody

Catalogue No.

STJ90060

Reactivity

Human, Mouse, Rat

Specificity

Cleaved-MMP-14 (Y112) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-14 protein resulting from cleavage adjacent to Y112.

Immunogen

Synthesized peptide derived from Cleaved-MMP-14 (Y112) at AA range 70-150

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

53 kDa

Formulation

Cleaved-MMP-14 (Y112) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-MMP-14 (Y112) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Matrix metalloproteinase-14 antibody, MMP-14 antibody, MMP-X1 antibody, Membrane-type matrix metalloproteinase 1 antibody, MT-MMP 1 antibody, MTMMP1 antibody, Membrane-type-1 matrix metalloproteinase antibody, MT1-MMP antibody, MT1MMP antibody

Database links

Human UniProt/Swiss-Prot:P50281;Mouse UniPort/Swiss-Prot: P53690;Rat UniProt/Swiss-Port: Q10739;Human Entrez Gene: 4323;Mouse Entrez Gene: 17387;Rat Entrez Gene: Rn.10371

Protein names

Matrix metalloproteinase-14 , MMP-14 , MMP-X1 , Membrane-type matrix metalloproteinase 1 , MT-MMP 1 , MTMMP1 , Membrane-type-1 matrix metalloproteinase , MT1-MMP , MT1MMP

Protein function

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. / Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-, -Leu-38. Other bonds hydrolyzed include 35-Gly-, -Ile-36 in the propeptide of collagenase 3, and 341-Asn-, -Phe-342, 441-Asp-, -Leu-442 and 354-Gln-, -Thr-355 in the aggrecan interglobular domain. / Zn2+ / Ca2+

Protein tissue specificity

Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.

Involvement in disease

Winchester syndrome (WNCHRS) [MIM:277950]: A disease characterized by severe osteolysis in the hands and feet, generalized osteoporosis, bone thinning, and absence of subcutaneous nodules. Various additional features include coarse face, corneal opacities, gum hypertrophy, and EKG changes. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. / Belongs to the peptidase M10A family. / Contains 4 hemopexin repeats.

Protein post-translational modifications

The precursor is cleaved by a furin endopeptidase. / Tyrosine phosphorylated by PKDCC/VLK.

Protein cellular localization

Membrane / Melanosome / Cytoplasm

Research area

All research areas>Synthesis and Degradation>MT-MMP-1
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize Cleaved-MMP-14 (Y112) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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