Rabbit Polyclonal Cleaved-MMP-17 (Q129) antibody (STJ90062)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-MMP-17 (Q129) antibody (STJ90062)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cleaved-MMP-17 (Q129) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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MMP17 antibody, MT4MMP antibody,|Matrix metalloproteinase 17 antibody|Matrix metalloproteinase 17 membrane inserted antibody|Matrix metalloproteinase-17 antibody|Membrane type 4 matrix metalloproteinase antibody|Membrane type matrix metalloproteinase 4 antibody|Membrane-type matrix metalloproteinase 4 antibody|Membrane-type-4 matrix metalloproteinase antibody|MMP 17 antibody|MMP-17 antibody|Mmp17 antibody|MMP17_HUMAN antibody|MT MMP 4 antibody|MT MMP4 antibody|MT-MMP 4 antibody|MT4 MMP antibody|MT4-MMP antibody|MT4MMP antibody|MTMMP 4 antibody|MTMMP4 antibody|Anti-MMP17 antibody [EP1270Y] (ab51075)
SCBT cat No: sc-8847|sc-13972|

 

Name

Cleaved-MMP-17 (Q129) Polyclonal Antibody

Catalogue No.

STJ90062

Reactivity

Human

Specificity

Cleaved-MMP-17 (Q129) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-17 protein resulting from cleavage adjacent to Q129.

Immunogen

Synthesized peptide derived from Cleaved-MMP-17 (Q129) at AA range 80-160

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

53 kDa

Formulation

Cleaved-MMP-17 (Q129) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-MMP-17 (Q129) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Matrix metalloproteinase-17 antibody, MMP-17 antibody, Membrane-type matrix metalloproteinase 4 antibody, MT-MMP 4 antibody, MTMMP4 antibody, Membrane-type-4 matrix metalloproteinase antibody, MT4-MMP antibody, MT4MMP antibody

Database links

Human UniProt/Swiss-Prot:Q9ULZ9;Mouse UniPort/Swiss-Prot: Q9R0S3;Rat UniProt/Swiss-Port: D3ZXJ0;Human Entrez Gene: 4326;Mouse Entrez Gene: 23948;Rat Entrez Gene: Rn.7971

Protein names

Matrix metalloproteinase-17 , MMP-17 , Membrane-type matrix metalloproteinase 4 , MT-MMP 4 , MTMMP4 , Membrane-type-4 matrix metalloproteinase , MT4-MMP , MT4MMP

Protein function

Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. / Cleaves pro-TNF-alpha at the 74-Ala-, -Gln-75 site. / Zn2+ / Ca2+

Protein tissue specificity

Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.

Protein sequence and domain

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. / Belongs to the peptidase M10A family. / Contains 4 hemopexin repeats.

Protein post-translational modifications

The precursor is cleaved by a furin endopeptidase.

Protein cellular localization

Cell membrane; Lipid-anchor > GPI-anchor; Extracellular side / Secreted > extracellular space > extracellular matrix

Research area

All research areas>Synthesis and Degradation>MMP
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize Cleaved-MMP-17 (Q129) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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