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Rabbit Polyclonal Cleaved-MMP-3 (F100) antibody (STJ90065)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-MMP-3 (F100) Polyclonal Antibody.
Check alternative names for the antibodyExpand
MMP3 antibody, STMY1 antibody,|CHDS6 antibody|Matrix metalloproteinase 3 antibody|Matrix metalloproteinase-3 antibody|MGC126102 antibody|MGC126103 antibody|MGC126104 antibody|MMP 3 antibody|MMP-3 antibody|MMP3 antibody|MMP3_HUMAN antibody|Proteoglycanase antibody|SL-1 antibody|SL1 antibody|STMY antibody|STMY1 antibody|STR1 antibody|Stromelysin 1 antibody|Stromelysin-1 antibody|Transin 1 antibody|Transin-1 antibody|Anti-MMP3 antibody (ab53015)
SCBT cat No: sc-31074|
Cleaved-MMP-3 (F100) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-MMP-3 (F100) Polyclonal Antibody detects endogenous levels of fragment of activated MMP-3 protein resulting from cleavage adjacent to F100.
Synthesized peptide derived from Cleaved-MMP-3 (F100) at AA range 50-130
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Cleaved-MMP-3 (F100) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-MMP-3 (F100) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Stromelysin-1 antibody, SL-1 antibody, Matrix metalloproteinase-3 antibody, MMP-3 antibody, Transin-1 antibody
|Protein names|| |
Stromelysin-1 , SL-1 , Matrix metalloproteinase-3 , MMP-3 , Transin-1
|Protein function|| |
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. / Preferential cleavage where P1′, P2′ and P3′ are hydrophobic residues. / Ca2+ / Zn2+
|Involvement in disease|| |
Coronary heart disease 6 (CHDS6) [MIM:614466]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.
|Protein sequence and domain|| |
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. / Belongs to the peptidase M10A family. / Contains 4 hemopexin repeats.
|Protein cellular localization|| |
Secreted > extracellular space > extracellular matrix
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St John’s Laboratory Ltd.
|Product type|| |
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