Rabbit Polyclonal Cleaved-Notch 2 (A1734) antibody (STJ90067)


Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-Notch 2 (A1734) antibody (STJ90067)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


NOTCH2 antibody,|AGS2 antibody|Aicardi-Goutieres syndrome 2 protein antibody|Deleted in lymphocytic leukemia 8 antibody|DLEU8 antibody|FLJ11712 antibody|Ribonuclease H2 subunit B antibody|Ribonuclease HI subunit B antibody|RNase H2 subunit B antibody|Rnaseh2b antibody|RNH2B_HUMAN antibody|Anti-Notch2 antibody (ab8926)
SCBT cat No: sc-7423|



Cleaved-Notch 2 (A1734) Polyclonal Antibody

Catalogue No.



Human, Mouse, Rat


Cleaved-Notch 2 (A1734) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 2 protein resulting from cleavage adjacent to A1734.


Synthesized peptide derived from Cleaved-Notch 2 (A1734) at AA range 1690-1770





Recommended dilution

WB 1:500-1:2000; ELISA 1:10000;







Molecular weight

79 kDa


Cleaved-Notch 2 (A1734) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


Cleaved-Notch 2 (A1734) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Neurogenic locus notch homolog protein 2 antibody, Notch 2 antibody, hN2 antibody

Database links

Human UniProt/Swiss-Prot:Q04721;Mouse UniPort/Swiss-Prot: O35516;Rat UniProt/Swiss-Port: G3V8G9;Human Entrez Gene: 4853;Mouse Entrez Gene: 18129;

Protein names

Neurogenic locus notch homolog protein 2 , Notch 2 , hN2

Protein function

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells .

Protein tissue specificity

Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.

Involvement in disease

Alagille syndrome 2 (ALGS2) [MIM:610205]: A form of Alagille syndrome, an autosomal dominant multisystem disorder. It is clinically defined by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Hajdu-Cheney syndrome (HJCYS) [MIM:102500]: A rare skeletal disorder characterized by the association of facial anomalies, acro-osteolysis, general osteoporosis, insufficient ossification of the skull, and periodontal disease (premature loss of permanent teeth). Other features include cleft palate, congenital heart defects, polycystic kidneys, orthopedic problems and anomalies of the genitalia, intestines and eyes. . Note: The disease is caused by mutations affecting the gene represented in this entry. NOTCH2 mutations associated with Hajdu-Cheney syndrome cluster to the last coding exon of the gene. This suggests that the mutant mRNA products may escape nonsense-mediated decay and the resulting truncated NOTCH2 proteins act in a gain-of-function manner.

Protein sequence and domain

Belongs to the NOTCH family. / Contains 6 ANK repeats. / Contains 35 EGF-like domains. / Contains 3 LNR (Lin/Notch) repeats.

Protein post-translational modifications

Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity). / Hydroxylated by HIF1AN. / Can be either O-glucosylated or O-xylosylated at Ser-613 by POGLUT1.

Protein cellular localization

Cell membrane / Single-pass type I membrane protein / Nucleus / Cytoplasm

Research area

All research areas>Membrane Receptors>Notch
(View all antibody categories related to Membrane Receptors)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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