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Rabbit Polyclonal Cleaved-Notch 2 (A1734) antibody (STJ90067)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-Notch 2 (A1734) Polyclonal Antibody.
Check alternative names for the antibodyExpand
NOTCH2 antibody,|AGS2 antibody|Aicardi-Goutieres syndrome 2 protein antibody|Deleted in lymphocytic leukemia 8 antibody|DLEU8 antibody|FLJ11712 antibody|Ribonuclease H2 subunit B antibody|Ribonuclease HI subunit B antibody|RNase H2 subunit B antibody|Rnaseh2b antibody|RNH2B_HUMAN antibody|Anti-Notch2 antibody (ab8926)
SCBT cat No: sc-7423|
Cleaved-Notch 2 (A1734) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Cleaved-Notch 2 (A1734) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 2 protein resulting from cleavage adjacent to A1734.
Synthesized peptide derived from Cleaved-Notch 2 (A1734) at AA range 1690-1770
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
Cleaved-Notch 2 (A1734) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-Notch 2 (A1734) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Neurogenic locus notch homolog protein 2 antibody, Notch 2 antibody, hN2 antibody
|Protein names|| |
Neurogenic locus notch homolog protein 2 , Notch 2 , hN2
|Protein function|| |
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells .
|Protein tissue specificity|| |
Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.
|Involvement in disease|| |
Alagille syndrome 2 (ALGS2) [MIM:610205]: A form of Alagille syndrome, an autosomal dominant multisystem disorder. It is clinically defined by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Hajdu-Cheney syndrome (HJCYS) [MIM:102500]: A rare skeletal disorder characterized by the association of facial anomalies, acro-osteolysis, general osteoporosis, insufficient ossification of the skull, and periodontal disease (premature loss of permanent teeth). Other features include cleft palate, congenital heart defects, polycystic kidneys, orthopedic problems and anomalies of the genitalia, intestines and eyes. . Note: The disease is caused by mutations affecting the gene represented in this entry. NOTCH2 mutations associated with Hajdu-Cheney syndrome cluster to the last coding exon of the gene. This suggests that the mutant mRNA products may escape nonsense-mediated decay and the resulting truncated NOTCH2 proteins act in a gain-of-function manner.
|Protein sequence and domain|| |
Belongs to the NOTCH family. / Contains 6 ANK repeats. / Contains 35 EGF-like domains. / Contains 3 LNR (Lin/Notch) repeats.
|Protein post-translational modifications|| |
Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity). / Hydroxylated by HIF1AN. / Can be either O-glucosylated or O-xylosylated at Ser-613 by POGLUT1.
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein / Nucleus / Cytoplasm
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St John’s Laboratory Ltd.
|Product type|| |
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