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Rabbit Polyclonal Cleaved-Notch 4 (V1432) antibody (STJ90070)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-Notch 4 (V1432) Polyclonal Antibody.
Check alternative names for the antibodyExpand
NOTCH4 antibody, INT3 antibody,|FLJ16302 antibody|hNotch 4 antibody|hNotch4 antibody|INT3 antibody|Neurogenic locus notch homolog protein 4 antibody|NOTC4_HUMAN antibody|Notch 4 antibody|Notch 4 intracellular domain antibody|Notch homolog 4 antibody|NOTCH3 antibody|Notch4 antibody|NOTCH4 protein antibody|Anti-NOTCH4 antibody [EPR18049] (ab184742)
SCBT cat No: sc-377399|sc-32634|sc-32613|sc-32612|
Cleaved-Notch 4 (V1432) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-Notch 4 (V1432) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 4 protein resulting from cleavage adjacent to V1432.
Synthesized peptide derived from Cleaved-Notch 4 (V1432) at AA range 1370-1450
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:5000;
|Molecular weight|| |
Cleaved-Notch 4 (V1432) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-Notch 4 (V1432) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Neurogenic locus notch homolog protein 4 antibody, Notch 4 antibody, hNotch4 antibody
|Protein names|| |
Neurogenic locus notch homolog protein 4 , Notch 4 , hNotch4
|Protein function|| |
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).
|Protein tissue specificity|| |
Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
|Protein sequence and domain|| |
Belongs to the NOTCH family. / Contains 5 ANK repeats. / Contains 29 EGF-like domains. / Contains 3 LNR (Lin/Notch) repeats.
|Protein post-translational modifications|| |
Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity). / Phosphorylated.
|Protein cellular localization|| |
Cell membrane; Single-pass type I membrane protein / Nucleus
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St John’s Laboratory Ltd.
|Product type|| |
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