Rabbit Polyclonal Cleaved-Notch 4 (V1432) antibody (STJ90070)

$99.00$319.00

Reactivity: Human, Monkey
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-Notch 4 (V1432) antibody (STJ90070)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cleaved-Notch 4 (V1432) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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NOTCH4 antibody, INT3 antibody,|FLJ16302 antibody|hNotch 4 antibody|hNotch4 antibody|INT3 antibody|Neurogenic locus notch homolog protein 4 antibody|NOTC4_HUMAN antibody|Notch 4 antibody|Notch 4 intracellular domain antibody|Notch homolog 4 antibody|NOTCH3 antibody|Notch4 antibody|NOTCH4 protein antibody|Anti-NOTCH4 antibody [EPR18049] (ab184742)
SCBT cat No: sc-377399|sc-32634|sc-32613|sc-32612|

 

Name

Cleaved-Notch 4 (V1432) Polyclonal Antibody

Catalogue No.

STJ90070

Reactivity

Human, Monkey

Specificity

Cleaved-Notch 4 (V1432) Polyclonal Antibody detects endogenous levels of fragment of activated Notch 4 protein resulting from cleavage adjacent to V1432.

Immunogen

Synthesized peptide derived from Cleaved-Notch 4 (V1432) at AA range 1370-1450

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

59 kDa

Formulation

Cleaved-Notch 4 (V1432) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-Notch 4 (V1432) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Neurogenic locus notch homolog protein 4 antibody, Notch 4 antibody, hNotch4 antibody

Database links

Human UniProt/Swiss-Prot:Q99466;Mouse UniPort/Swiss-Prot: P31695;Rat UniProt/Swiss-Port: Q6MG89;Human Entrez Gene: 4855;Mouse Entrez Gene: 18132;Rat Entrez Gene: Rn.12967

Protein names

Neurogenic locus notch homolog protein 4 , Notch 4 , hNotch4

Protein function

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).

Protein tissue specificity

Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.

Protein sequence and domain

Belongs to the NOTCH family. / Contains 5 ANK repeats. / Contains 29 EGF-like domains. / Contains 3 LNR (Lin/Notch) repeats.

Protein post-translational modifications

Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity). / Phosphorylated.

Protein cellular localization

Cell membrane; Single-pass type I membrane protein / Nucleus

Research area

All research areas>Membrane Receptors>Notch
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize Cleaved-Notch 4 (V1432) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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