Rabbit Polyclonal Cleaved-PARP-1 (G215) antibody (STJ90072)

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Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-PARP-1 (G215) antibody (STJ90072)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:5000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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PARP1 antibody, ADPRT antibody, PPOL antibody,|ADP-ribosyltransferase diphtheria toxin-like 1 antibody|ADPRT 1 antibody|ADPRT antibody|ADPRT1 antibody|APOPAIN antibody|ARTD1 antibody|NAD(+) ADP-ribosyltransferase 1 antibody|PARP antibody|PARP-1 antibody|PARP1 antibody|PARP1_HUMAN antibody|Poly [ADP-ribose] polymerase 1 antibody|Poly ADP ribose polymerase 1 antibody|Poly[ADP-ribose] synthase 1 antibody|PPOL antibody|SCA1 antibody|Anti-Cleaved PARP antibody [E51] (ab32064)
SCBT cat No: sc-23461|sc-56196|sc-56217|sc-52953|sc-71965|sc-23465|sc-23464|sc-23335|sc-73850|sc-49413|sc-49414|sc-393134|sc-390005|

 

Name

Cleaved-PARP-1 (G215) Polyclonal Antibody

Catalogue No.

STJ90072

Reactivity

Human

Specificity

Cleaved-PARP-1 (G215) Polyclonal Antibody detects endogenous levels of fragment of activated PARP-1 protein resulting from cleavage adjacent to G215.

Immunogen

Synthesized peptide derived from Cleaved-PARP-1 (G215) at AA range 170-250

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:5000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

89 kDa

Formulation

Cleaved-PARP-1 (G215) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-PARP-1 (G215) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Poly polymerase 1 antibody, PARP-1 antibody, ADP-ribosyltransferase diphtheria toxin-like 1 antibody, ARTD1 antibody, NADantibody, + antibody, ADP-ribosyltransferase 1 antibody, ADPRT 1 antibody, Poly synthase 1 antibody

Database links

Human UniProt/Swiss-Prot:P09874;Rat UniProt/Swiss-Port: P27008;Human Entrez Gene: 142;Mouse Entrez Gene: 11545;Rat Entrez Gene: Rn.11327

Protein names

Poly polymerase 1 , PARP-1 , ADP-ribosyltransferase diphtheria toxin-like 1 , ARTD1 , NAD, + , ADP-ribosyltransferase 1 , ADPRT 1 , Poly synthase 1

Protein function

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. / NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Protein sequence and domain

Contains 1 BRCT domain. / Contains 1 PARP alpha-helical domain. / Contains 1 PARP catalytic domain. / Contains 2 PARP-type zinc fingers.

Protein post-translational modifications

Phosphorylated by PRKDC and TXK. / Poly-ADP-ribosylated by PARP2. Poly-ADP-ribosylation mediates the recruitment of CHD1L to DNA damage sites. / S-nitrosylated, leading to inhibit transcription regulation activity.

Protein cellular localization

Nucleus / Nucleus > nucleolus

Research area

All research areas>Transcription Regulators>PARP
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Cleaved-PARP-1 (G215) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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