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Rabbit Polyclonal Cleaved-Plasminogen HC A short form (V98) antibody (STJ90102)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-Plasminogen HC A short form (V98) Polyclonal Antibody.
Check alternative names for the antibodyExpand
PLG antibody,|Angiostatin antibody|DKFZp779M0222 antibody|Plasmin antibody|Plasmin heavy chain A antibody|Plasmin light chain B antibody|Plasminogen antibody|PLG antibody|PLMN_HUMAN antibody|Anti-Plasminogen antibody (ab154560)
SCBT cat No: sc-15036|
Cleaved-Plasminogen HC A short form (V98) Polyclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat
Cleaved-Plasminogen HC A short form (V98) Polyclonal Antibody detects endogenous levels of fragment of activated Plasminogen HC A short form protein resulting from cleavage adjacent to V98.
Synthesized peptide derived from Cleaved-Plasminogen HC A short form (V98) at AA range 50-130
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000;
|Molecular weight|| |
Cleaved-Plasminogen HC A short form (V98) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-Plasminogen HC A short form (V98) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Plasminogen antibody, antibody
|Protein names|| |
|Protein function|| |
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. / Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. / Preferential cleavage: Lys-, -Xaa > Arg-, -Xaa; higher selectivity than trypsin. Converts fibrin into soluble products. / Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase. Plasmin activity inhibited by SERPINE2.
|Protein tissue specificity|| |
Present in plasma and many other extracellular fluids. It is synthesized in the liver.
|Involvement in disease|| |
Plasminogen deficiency (PLGD) [MIM:217090]: A disorder characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Kringle domains mediate interaction with CSPG4. / Belongs to the peptidase S1 family. Plasminogen subfamily. / Contains 5 kringle domains. / Contains 1 PAN domain. / Contains 1 peptidase S1 domain.
|Protein post-translational modifications|| |
N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity). / In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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