Rabbit Polyclonal Cleaved-Spectrin alpha II (D1185) antibody (STJ90073)

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Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-Spectrin alpha II (D1185) antibody (STJ90073)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cleaved-Spectrin alpha II (D1185) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

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SPTAN1 antibody, NEAS antibody, SPTA2 antibody,|(ALPHA)II-SPECTRIN antibody|Alpha II Spectrin antibody|Alpha-II spectrin antibody|brain antibody|EIEE5 antibody|FLJ17738 antibody|FLJ44613 antibody|Fodrin alpha chain antibody|Fodrin, alpha antibody|NEAS antibody|Non erythrocytic spectrin alpha antibody|non-erythroid alpha chain antibody|SPECA antibody|Spectrin alpha chain antibody|Spectrin alpha chain brain antibody|Spectrin alpha non erythrocytic 1 antibody|Spectrin antibody|Spectrin non erythroid alpha chain antibody|Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) antibody|Spectrin, nonerythroid, alpha subunit antibody|Spna2 antibody|SPTA 2 antibody|SPTA2 antibody|SPTA2_HUMAN antibody|SPTAN 1 antibody|SPTAN1 antibody|Anti-Alpha Fodrin antibody [D8B7] (ab11755)
SCBT cat No: sc-23465|sc-23464|sc-23335|sc-73850|sc-49413|sc-49414|sc-393134|sc-390005|

 

Name

Cleaved-Spectrin alpha II (D1185) Polyclonal Antibody

Catalogue No.

STJ90073

Reactivity

Human

Specificity

Cleaved-Spectrin alpha II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin alpha II protein resulting from cleavage adjacent to D1185.

Immunogen

Synthesized peptide derived from Cleaved-Spectrin alpha II (D1185) at AA range 1110-1190

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

137 kDa

Formulation

Cleaved-Spectrin alpha II (D1185) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-Spectrin alpha II (D1185) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Spectrin alpha chain, non-erythrocytic 1 antibody, Alpha-II spectrin antibody, Fodrin alpha chain antibody, Spectrin, non-erythroid alpha subunit antibody

Database links

Human UniProt/Swiss-Prot:Q13813;Rat UniProt/Swiss-Port: P16086;Human Entrez Gene: 6709;Mouse Entrez Gene: 20740;Rat Entrez Gene: Rn.5812

Protein names

Spectrin alpha chain, non-erythrocytic 1 , Alpha-II spectrin , Fodrin alpha chain , Spectrin, non-erythroid alpha subunit

Protein function

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Involvement in disease

Epileptic encephalopathy, early infantile, 5 (EIEE5) [MIM:613477]: A disorder characterized by seizures associated with hypsarrhythmia, profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the spectrin family. / Contains 3 EF-hand domains. / Contains 1 SH3 domain. / Contains 23 spectrin repeats.

Protein post-translational modifications

Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.

Protein cellular localization

Cytoplasm > cytoskeleton / Cytoplasm > cell cortex

Research area

All research areas>Structural Proteins>spectrin
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize Cleaved-Spectrin alpha II (D1185) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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