Rabbit Polyclonal Cleaved-SUMO-2/3 (G93) antibody (STJ90074)

$99.00$319.00

Reactivity: Human, Mouse, Rat
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-SUMO-2/3 (G93) antibody (STJ90074)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

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SUMO2 antibody, SMT3B antibody, SMT3H2 antibody,|HSMT3 antibody|small ubiquitin-like modifier 3 antibody|SMT3 homolog 1 antibody|SMT3 homolog 2 antibody|SMT3 suppressor of mif two 3 homolog 1 antibody|SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) antibody|SMT3 suppressor of mif two 3 homolog 2 antibody|SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) antibody|SMT3 suppressor of mif two 3 homolog 3 antibody|SMT3A antibody|SMT3B antibody|SMT3H1 antibody|SMT3H2 antibody|Sumo2 antibody|Sumo3 antibody|Ubiquitin like protein SMT3A antibody|Ubiquitin like protein SMT3B antibody|Anti-Sumo 2+3 antibody (ab3742)
SCBT cat No: To be updated

 

Name

Cleaved-SUMO-2/3 (G93) Polyclonal Antibody

Catalogue No.

STJ90074

Reactivity

Human, Mouse, Rat

Specificity

Cleaved-SUMO-2/3 (G93) Polyclonal Antibody detects endogenous levels of fragment of activated SUMO-2/3 protein resulting from cleavage adjacent to G93.

Immunogen

Synthesized peptide derived from Cleaved-SUMO-2/3 (G93) at AA range 20-100

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

11 kDa

Formulation

Cleaved-SUMO-2/3 (G93) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-SUMO-2/3 (G93) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Small ubiquitin-related modifier 2 antibody, SUMO-2 antibody, HSMT3 antibody, SMT3 homolog 2 antibody, SUMO-3 antibody, Sentrin-2 antibody, Ubiquitin-like protein SMT3B antibody, Smt3B antibody

Database links

Human UniProt/Swiss-Prot:P61956;Mouse UniPort/Swiss-Prot: P61957;Rat UniProt/Swiss-Port: P61959;Human Entrez Gene: 6613;Mouse Entrez Gene: 170930;Rat Entrez Gene: Rn.154659

Protein names

Small ubiquitin-related modifier 2 , SUMO-2 , HSMT3 , SMT3 homolog 2 , SUMO-3 , Sentrin-2 , Ubiquitin-like protein SMT3B , Smt3B

Protein function

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 . This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins . Plays a role in the regulation of sumoylation status of SETX .

Protein tissue specificity

Broadly expressed.

Protein sequence and domain

Belongs to the ubiquitin family. SUMO subfamily. / Contains 1 ubiquitin-like domain.

Protein post-translational modifications

Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo ‘Lys-6’-, ‘Lys-11’-, ‘Lys-48’- and ‘Lys-63’-linked polyubiquitination by RNF4. / Cleavage of precursor form by SENP1 or SENP2 is necessary for function. / Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.

Protein cellular localization

Nucleus / Nucleus > PML body

Research area

All research areas>Synthesis and Degradation>SUMO
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize Cleaved-SUMO-2/3 (G93) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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