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Rabbit Polyclonal Cleaved-TACE (R215) antibody (STJ90075)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-TACE (R215) Polyclonal Antibody.
Check alternative names for the antibodyExpand
ADAM17 antibody, CSVP antibody, TACE antibody,|A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) antibody|A disintegrin and metalloproteinase domain 17 antibody|ADA17_HUMAN antibody|ADAM 17 antibody|ADAM metallopeptidase domain 17 antibody|ADAM17 antibody|ADAM17 protein antibody|CD 156b antibody|CD156b antibody|CD156b antigen antibody|CSVP antibody|Disintegrin and metalloproteinase domain-containing protein 17 antibody|MGC71942 antibody|NISBD antibody|NISBD1 antibody|Snake venom like protease antibody|Snake venom-like protease antibody|TACE antibody|TNF alpha convertase antibody|TNF alpha converting enzyme antibody|TNF-alpha convertase antibody|TNF-alpha-converting enzyme antibody|Tumor Necrosis Factor Alpha Converting Enzyme antibody|Anti-ADAM17 antibody (ab2051)
SCBT cat No: To be updated
Cleaved-TACE (R215) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-TACE (R215) Polyclonal Antibody detects endogenous levels of fragment of activated TACE protein resulting from cleavage adjacent to R215.
Synthesized peptide derived from Cleaved-TACE (R215) at AA range 170-250
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Cleaved-TACE (R215) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-TACE (R215) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Disintegrin and metalloproteinase domain-containing protein 17 antibody, ADAM 17 antibody, Snake venom-like protease antibody, TNF-alpha convertase antibody, TNF-alpha-converting enzyme antibody, CD antigen CD156b antibody
|Protein names|| |
Disintegrin and metalloproteinase domain-containing protein 17 , ADAM 17 , Snake venom-like protease , TNF-alpha convertase , TNF-alpha-converting enzyme , CD antigen CD156b
|Protein function|| |
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. / Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-, -Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to ‘shed’ the extracellular domains. / Zn2+
|Protein tissue specificity|| |
Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
|Involvement in disease|| |
Inflammatory skin and bowel disease, neonatal, 1 (NISBD1) [MIM:614328]: A disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity). / The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. / Contains 1 disintegrin domain. / Contains 1 peptidase M12B domain.
|Protein post-translational modifications|| |
The precursor is cleaved by a furin endopeptidase. / Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding.
|Protein cellular localization|| |
Membrane; Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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