Rabbit Polyclonal Cleaved-TACE (R215) antibody (STJ90075)

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Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-TACE (R215) antibody (STJ90075)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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ADAM17 antibody, CSVP antibody, TACE antibody,|A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) antibody|A disintegrin and metalloproteinase domain 17 antibody|ADA17_HUMAN antibody|ADAM 17 antibody|ADAM metallopeptidase domain 17 antibody|ADAM17 antibody|ADAM17 protein antibody|CD 156b antibody|CD156b antibody|CD156b antigen antibody|CSVP antibody|Disintegrin and metalloproteinase domain-containing protein 17 antibody|MGC71942 antibody|NISBD antibody|NISBD1 antibody|Snake venom like protease antibody|Snake venom-like protease antibody|TACE antibody|TNF alpha convertase antibody|TNF alpha converting enzyme antibody|TNF-alpha convertase antibody|TNF-alpha-converting enzyme antibody|Tumor Necrosis Factor Alpha Converting Enzyme antibody|Anti-ADAM17 antibody (ab2051)
SCBT cat No: To be updated

 

Name

Cleaved-TACE (R215) Polyclonal Antibody

Catalogue No.

STJ90075

Reactivity

Human

Specificity

Cleaved-TACE (R215) Polyclonal Antibody detects endogenous levels of fragment of activated TACE protein resulting from cleavage adjacent to R215.

Immunogen

Synthesized peptide derived from Cleaved-TACE (R215) at AA range 170-250

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

65 kDa

Formulation

Cleaved-TACE (R215) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-TACE (R215) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Disintegrin and metalloproteinase domain-containing protein 17 antibody, ADAM 17 antibody, Snake venom-like protease antibody, TNF-alpha convertase antibody, TNF-alpha-converting enzyme antibody, CD antigen CD156b antibody

Database links

Human UniProt/Swiss-Prot:P78536;Mouse UniPort/Swiss-Prot: Q9Z0F8;Rat UniProt/Swiss-Port: Q9Z1K9;Human Entrez Gene: 6868;Mouse Entrez Gene: 11491;Rat Entrez Gene: Rn.144585

Protein names

Disintegrin and metalloproteinase domain-containing protein 17 , ADAM 17 , Snake venom-like protease , TNF-alpha convertase , TNF-alpha-converting enzyme , CD antigen CD156b

Protein function

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. / Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-, -Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to ‘shed’ the extracellular domains. / Zn2+

Protein tissue specificity

Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.

Involvement in disease

Inflammatory skin and bowel disease, neonatal, 1 (NISBD1) [MIM:614328]: A disorder characterized by inflammatory features with neonatal onset, involving the skin, hair, and gut. The skin lesions involve perioral and perianal erythema, psoriasiform erythroderma, with flares of erythema, scaling, and widespread pustules. Gastrointestinal symptoms include malabsorptive diarrhea that is exacerbated by intercurrent gastrointestinal infections. The hair is short or broken, and the eyelashes and eyebrows are wiry and disorganized. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity). / The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. / Contains 1 disintegrin domain. / Contains 1 peptidase M12B domain.

Protein post-translational modifications

The precursor is cleaved by a furin endopeptidase. / Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791. Phosphorylation at THR-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding.

Protein cellular localization

Membrane; Single-pass type I membrane protein

Research area

All research areas>Synthesis and Degradation>TACE
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize Cleaved-TACE (R215) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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