Rabbit Polyclonal Cleaved-Thrombin APII (R327) antibody (STJ90076)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit Polyclonal Cleaved-Thrombin APII (R327) antibody (STJ90076)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Cleaved-Thrombin APII (R327) Polyclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

F2 antibody,|antithrombin III antibody|AT3 antibody|AT3D antibody|ATIII antibody|coagulation factor II (thrombin) antibody|F2 antibody|PRO0309 antibody|prothrombin antibody|prothrombin B chain antibody|PT antibody|RPRGL2 antibody|serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 antibody|serine protease antibody|serine-cysteine proteinase inhibitor clade C member 1 antibody|serpin C1 antibody|serpin peptidase inhibitor, clade C (antithrombin), member 1 antibody|SERPINC1 antibody|TAT antibody|THPH1 antibody|THPH7 antibody|Anti-Thrombin-Antithrombin Complex antibody [22] (ab191378)
SCBT cat No: sc-136449|sc-69769|sc-73470|sc-101956|sc-81983|sc-47730|sc-58581|sc-52969|sc-47729|sc-69896|sc-7693|

 

Name

Cleaved-Thrombin APII (R327) Polyclonal Antibody

Catalogue No.

STJ90076

Reactivity

Human

Specificity

Cleaved-Thrombin APII (R327) Polyclonal Antibody detects endogenous levels of fragment of activated Thrombin APII protein resulting from cleavage adjacent to R327.

Immunogen

Synthesized peptide derived from Cleaved-Thrombin APII (R327) at AA range 250-330

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:20000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

19 kDa

Formulation

Cleaved-Thrombin APII (R327) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-Thrombin APII (R327) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Prothrombin antibody, Coagulation factor II antibody

Database links

Human UniProt/Swiss-Prot:P00734;Mouse UniPort/Swiss-Prot: P19221;Rat UniProt/Swiss-Port: G3V843;Human Entrez Gene: 2147;Mouse Entrez Gene: 14061;Rat Entrez Gene: Rn.54498

Protein names

Prothrombin , Coagulation factor II

Protein function

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. / Selective cleavage of Arg-, -Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. / Inhibited by SERPINA5.

Protein tissue specificity

Expressed by the liver and secreted in plasma.

Involvement in disease

Factor II deficiency (FA2D) [MIM:613679]: A very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Thrombophilia due to thrombin defect (THPH1) [MIM:188050]: A multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. . Note: The disease is caused by mutations affecting the gene represented in this entry. A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis.; Pregnancy loss, recurrent, 2 (RPRGL2) [MIM:614390]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase S1 family. / Contains 1 Gla (gamma-carboxy-glutamate) domain. / Contains 2 kringle domains. / Contains 1 peptidase S1 domain.

Protein post-translational modifications

The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin. / N-glycosylated. N-glycan heterogeneity at Asn-121: Hex3HexNAc3 (minor), Hex4HexNAc3 (minor) and Hex5HexNAc4 (major). At Asn-143: Hex4HexNAc3 (minor) and Hex5HexNAc4 (major).

Protein cellular localization

Secreted > extracellular space

Note

AntibodyPlus can customize Cleaved-Thrombin APII (R327) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!