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Rabbit Polyclonal Cleaved-Thrombin APII (R327) antibody (STJ90076)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:20000;
Recommended protocols: check protocols
Click or hover above images to see image description for Cleaved-Thrombin APII (R327) Polyclonal Antibody.
Check alternative names for the antibodyExpand
F2 antibody,|antithrombin III antibody|AT3 antibody|AT3D antibody|ATIII antibody|coagulation factor II (thrombin) antibody|F2 antibody|PRO0309 antibody|prothrombin antibody|prothrombin B chain antibody|PT antibody|RPRGL2 antibody|serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 antibody|serine protease antibody|serine-cysteine proteinase inhibitor clade C member 1 antibody|serpin C1 antibody|serpin peptidase inhibitor, clade C (antithrombin), member 1 antibody|SERPINC1 antibody|TAT antibody|THPH1 antibody|THPH7 antibody|Anti-Thrombin-Antithrombin Complex antibody  (ab191378)
SCBT cat No: sc-136449|sc-69769|sc-73470|sc-101956|sc-81983|sc-47730|sc-58581|sc-52969|sc-47729|sc-69896|sc-7693|
Cleaved-Thrombin APII (R327) Polyclonal Antibody
|Catalogue No.|| |
Cleaved-Thrombin APII (R327) Polyclonal Antibody detects endogenous levels of fragment of activated Thrombin APII protein resulting from cleavage adjacent to R327.
Synthesized peptide derived from Cleaved-Thrombin APII (R327) at AA range 250-330
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:20000;
|Molecular weight|| |
Cleaved-Thrombin APII (R327) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Cleaved-Thrombin APII (R327) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Prothrombin antibody, Coagulation factor II antibody
|Protein names|| |
Prothrombin , Coagulation factor II
|Protein function|| |
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. / Selective cleavage of Arg-, -Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. / Inhibited by SERPINA5.
|Protein tissue specificity|| |
Expressed by the liver and secreted in plasma.
|Involvement in disease|| |
Factor II deficiency (FA2D) [MIM:613679]: A very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.; Thrombophilia due to thrombin defect (THPH1) [MIM:188050]: A multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. . Note: The disease is caused by mutations affecting the gene represented in this entry. A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis.; Pregnancy loss, recurrent, 2 (RPRGL2) [MIM:614390]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. . Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the peptidase S1 family. / Contains 1 Gla (gamma-carboxy-glutamate) domain. / Contains 2 kringle domains. / Contains 1 peptidase S1 domain.
|Protein post-translational modifications|| |
The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin. / N-glycosylated. N-glycan heterogeneity at Asn-121: Hex3HexNAc3 (minor), Hex4HexNAc3 (minor) and Hex5HexNAc4 (major). At Asn-143: Hex4HexNAc3 (minor) and Hex5HexNAc4 (major).
|Protein cellular localization|| |
Secreted > extracellular space
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St John’s Laboratory Ltd.
|Product type|| |
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