Rabbit Polyclonal Cleaved-Tumstatin (P1426) antibody (STJ90077)

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Reactivity: Human, Monkey
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Rabbit Polyclonal Cleaved-Tumstatin (P1426) antibody (STJ90077)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:40000;

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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COL4A3 antibody,|Arresten antibody|CO4A1_HUMAN antibody|COL4A1 antibody|COL4A1 NC1 domain antibody|COL4A2 antibody|COL4A3 antibody|COL4A4 antibody|COL4A5 antibody|collagen alpha-1(IV) chain antibody|Collagen IV Alpha 1 Polypeptide antibody|Collagen IV Alpha 2 Polypeptide antibody|Collagen Of Basement Membrane Alpha 1 Chain antibody|Collagen Of Basement Membrane Alpha 2 Chain antibody|Collagen Type IV Alpha 1 antibody|Collagen Type IV Alpha 2 antibody|Collagen Type IV Alpha 3 antibody|Collagen Type IV Alpha 4 antibody|Collagen Type IV Alpha 5 antibody|Collagen Type IV antibody|Anti-Collagen IV antibody (ab6586)
SCBT cat No: sc-167523|sc-167524|

 

Name

Cleaved-Tumstatin (P1426) Polyclonal Antibody

Catalogue No.

STJ90077

Reactivity

Human, Monkey

Specificity

Cleaved-Tumstatin (P1426) Polyclonal Antibody detects endogenous levels of fragment of activated Tumstatin protein resulting from cleavage adjacent to P1426.

Immunogen

Synthesized peptide derived from Cleaved-Tumstatin (P1426) at AA range 1380-1460

Host

Rabbit

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:40000;

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

27 kDa

Formulation

Cleaved-Tumstatin (P1426) Antibody was tube-contained. Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Cleaved-Tumstatin (P1426) Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Collagen alpha-3antibody, IV antibody, chain antibody, Goodpasture antigen antibody

Database links

Human UniProt/Swiss-Prot:Q01955;Mouse UniPort/Swiss-Prot: Q9QZS0;Rat UniProt/Swiss-Port: F1LRJ1;Human Entrez Gene: 1285;Mouse Entrez Gene: 12828;Rat Entrez Gene: Rn.121139

Protein names

Collagen alpha-3, IV , chain , Goodpasture antigen

Protein function

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ‘chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen. / Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.

Protein tissue specificity

Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. According to PubMed:8083201, alpha 3 type IV collagen is not detected in heart, brain, placenta, liver, pancreas, extrasynaptic muscle fibers, endoneurial and perineurial nerves, fetal brain, fetal heart and fetal liver. According to PubMed:7523402, alpha 3 type IV collagen is strongly expressed in pancreas, neuroretina and calvaria and not expressed in adrenal, ileum and skin. Isoform 1 and isoform 3 are strongly expressed in kidney, lung, suprarenal capsule, muscle and spleen, in each of these tissues isoform 1 is more abundant than isoform 3. Isoform 1 and isoform 3 are expressed at low levels in artery, fat, pericardium and peripherical nerve, but not in placenta, mesangium, skin, pleura and cultured umbilical endothelial cells.

Involvement in disease

Note: Autoantibodies against the NC1 domain of alpha 3(IV) are found in Goodpasture syndrome, an autoimmune disease of lung and kidney.; Alport syndrome, autosomal recessive (APSAR) [MIM:203780]: A syndrome characterized by progressive glomerulonephritis, glomerular basement membrane defects, renal failure, sensorineural deafness and specific eye abnormalities (lenticonous and macular flecks). The disorder shows considerable heterogeneity in that families differ in the age of end-stage renal disease and the occurrence of deafness. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Hematuria, benign familial (BFH) [MIM:141200]: An autosomal dominant condition characterized by non-progressive isolated microscopic hematuria that does not result in renal failure. It is characterized pathologically by thinning of the glomerular basement membrane. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Alport syndrome, autosomal dominant (APSAD) [MIM:104200]: A syndrome characterized by progressive glomerulonephritis, glomerular basement membrane defects, renal failure, sensorineural deafness and specific eye abnormalities (lenticonous and macular flecks). The disorder shows considerable heterogeneity in that families differ in the age of end-stage renal disease and the occurrence of deafness. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain. / Belongs to the type IV collagen family. / Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.

Protein post-translational modifications

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. / Isoform 2 contains an additional N-linked glycosylation site. / Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. / The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues. / Phosphorylated by the Goodpasture antigen-binding protein/COL4A3BP.

Protein cellular localization

Secreted > extracellular space > extracellular matrix > basement membrane

Note

AntibodyPlus can customize Cleaved-Tumstatin (P1426) Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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