Rabbit polyclonal CLEC12A antibody (A6250)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CLEC12A antibody (A6250)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CLEC12A antibody.

Alternative names:

Check alternative names for the antibody

Expand

CLL1 antibody, MICL antibody, CLL-1 antibody, DCAL-2 antibody
C-type lectin domain family 12 member A antibody|C-type lectin-like molecule 1 antibody|CL12A_HUMAN antibody|CLEC12A antibody|CLL-1 antibody|DCAL-2 antibody|Dendritic cell-associated lectin 2 antibody|MICL antibody|Myeloid inhibitory C-type lectin-like receptor antibody|Anti-CLEC12A antibody (ab107494)

SCBT cat No: sc-109517|

Name

Rabbit polyclonal CLEC12A antibody

Catalogue No.

A6250

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CLEC12A

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 30kDa/Observed: Refer to Figures

Formulation

CLEC12A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CLEC12A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CLL1 antibody, MICL antibody, CLL-1 antibody, DCAL-2 antibody

Database links

Human UniProt/Swiss-Prot:Q5QGZ9

Protein names

CLL1, MICL, CLL-1, DCAL-2

Protein function

Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

Protein tissue specificity

Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.

Protein sequence and domain

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.Contains 1 C-type lectin domain.

Protein post-translational modifications

Highly N-glycosylated. Glycosylation varies between cell types.

Protein cellular localization

Cell membrane ; Single-pass type II membrane protein . Note: Ligand binding leads to internalization.

Background

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.

Note

AntibodyPlus can customize CLEC12A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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