Rabbit polyclonal CLIC1 antibody (A6363)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CLIC1 antibody (A6363)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CLIC1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

G6 antibody, NCC27 antibody
Chloride channel ABP antibody|Chloride intracellular channel 1 antibody|Chloride intracellular channel protein 1 antibody|CLIC 1 antibody|CLIC1 antibody|CLIC1_HUMAN antibody|G6 antibody|hRNCC antibody|NCC 27 antibody|NCC27 antibody|Nuclear chloride ion channel 27 antibody|Nuclear chloride ion channel protein antibody|p64CLCP antibody|Regulatory nuclear chloride ion channel protein antibody|RNCC protein antibody|Anti-CLIC1 antibody (ab77214)

SCBT cat No: sc-81873|sc-271051|sc-51048|sc-374202|sc-51049|

Name

Rabbit polyclonal CLIC1 antibody

Catalogue No.

A6363

Reactivity

Human

Immunogen

Recombinant protein of human CLIC1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 26kDa/Observed: Refer to Figures

Formulation

CLIC1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CLIC1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

G6 antibody, NCC27 antibody

Database links

Human UniProt/Swiss-Prot:O00299

Protein names

G6, NCC27

Protein function

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.

Protein tissue specificity

Expression is prominent in heart, placenta, liver, kidney and pancreas.

Protein sequence and domain

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.Belongs to the chloride channel CLIC family.; Contains 1 GST C-terminal domain.

Protein post-translational modifications

Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.

Protein cellular localization

Nucleus. Nucleus membrane ; Single-pass membrane protein . Cytoplasm. Cell membrane ; Single-pass membrane protein . Note: Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.

Background

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.

Research area

All research areas>Channel Proteins>CLIC
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize CLIC1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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