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Rabbit polyclonal CLIC1 antibody (A6363)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal CLIC1 antibody.
Check alternative names for the antibodyExpand
G6 antibody, NCC27 antibody
Chloride channel ABP antibody|Chloride intracellular channel 1 antibody|Chloride intracellular channel protein 1 antibody|CLIC 1 antibody|CLIC1 antibody|CLIC1_HUMAN antibody|G6 antibody|hRNCC antibody|NCC 27 antibody|NCC27 antibody|Nuclear chloride ion channel 27 antibody|Nuclear chloride ion channel protein antibody|p64CLCP antibody|Regulatory nuclear chloride ion channel protein antibody|RNCC protein antibody|Anti-CLIC1 antibody (ab77214)
SCBT cat No: sc-81873|sc-271051|sc-51048|sc-374202|sc-51049|
Rabbit polyclonal CLIC1 antibody
|Catalogue No.|| |
Recombinant protein of human CLIC1
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 26kDa/Observed: Refer to Figures
CLIC1 antibody was tube-contained.
CLIC1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
G6 antibody, NCC27 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
|Protein tissue specificity|| |
Expression is prominent in heart, placenta, liver, kidney and pancreas.
|Protein sequence and domain|| |
Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.Belongs to the chloride channel CLIC family.; Contains 1 GST C-terminal domain.
|Protein post-translational modifications|| |
Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.
|Protein cellular localization|| |
Nucleus. Nucleus membrane ; Single-pass membrane protein . Cytoplasm. Cell membrane ; Single-pass membrane protein . Note: Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
AntibodyPlus can customize CLIC1 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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