Rabbit polyclonal CLIC4 antibody (A7088)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CLIC4 antibody (A7088)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CLIC4 antibody.

Alternative names:

Check alternative names for the antibody

Expand

H1 antibody, huH1 antibody, p64H1 antibody, CLIC4L antibody, MTCLIC antibody
Chloride intracellular channel 4 antibody|Chloride intracellular channel 4 (mitochondrial) antibody|Chloride intracellular channel 4 like antibody|Chloride intracellular channel protein 4 antibody|Clic4 antibody|CLIC4_HUMAN antibody|CLIC4L antibody|DKFZP566G223 antibody|FLJ38640 antibody|H1 antibody|HUH1 antibody|Intracellular chloride ion channel protein p64H1 antibody|MC3S5 antibody|mtCLIC antibody|p64H1 antibody|Anti-CLIC4 antibody [EPR14253] (ab183043)

SCBT cat No: sc-135739|sc-130723|

Name

Rabbit polyclonal CLIC4 antibody

Catalogue No.

A7088

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CLIC4

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 29kDa/Observed: Refer to figures

Formulation

CLIC4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CLIC4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

H1 antibody, huH1 antibody, p64H1 antibody, CLIC4L antibody, MTCLIC antibody

Database links

Human UniProt/Swiss-Prot:Q9Y696

Protein names

H1, huH1, p64H1, CLIC4L, MTCLIC

Protein function

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

Protein tissue specificity

Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.

Protein sequence and domain

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.Belongs to the chloride channel CLIC family.; Contains 1 GST C-terminal domain.

Protein cellular localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane ; Single-pass membrane protein . Nucleus matrix. Cell membrane ; Single-pass membrane protein . Mitochondrion. Cell junction. Note: Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.

Background

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).

Research area

All research areas>Channel Proteins>CLIC
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize CLIC4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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