Rabbit Polyclonal CNDP2 antibody (A10381)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal CNDP2 antibody (A10381)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CN2 antibody; CPGL antibody; PEPA antibody; HsT2298 antibody; HEL-S-13 antibody;
0610010E05Rik antibody|C76600 antibody|Carnosinase , tissue antibody|Carnosinase 2 antibody|CN 2 antibody|CN2 antibody|CNDP 2 antibody|CNDP dipeptidase 2 (metallopeptidase M20 family) antibody|CNDP dipeptidase 2 antibody|CNDP2 antibody|CNDP2_HUMAN antibody|CPGL antibody|Cytosolic non specific dipeptidase antibody|Cytosolic non-specific dipeptidase antibody|Cytosolic nonspecific dipeptidase antibody|Dip-2 antibody|FLJ10830 antibody|FLJ35544 antibody|Glutamate carboxypeptidase like protein 1 antibody|Glutamate carboxypeptidase-like protein 1 antibody|HsT2298 antibody|Nonspecific dipeptidase, cutosolic antibody|Pep-1 antibody|Pep1 antibody|PEPA antibody|Peptidase A antibody|Anti-CNDP2 antibody (ab204351)

SCBT cat No:

Name

Rabbit Polyclonal CNDP2 antibody

Catalogue No.

A10381

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CNDP2

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

52kDa

Formulation

CNDP2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CN2 antibody; CPGL antibody; PEPA antibody; HsT2298 antibody; HEL-S-13 antibody;

Protein names

CN2; CPGL; PEPA; HsT2298; HEL-S-13;

Protein function

Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).

Protein tissue specificity

Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. Down-regulated in gastric cancer tissues (at protein level) (PubMed:24395568).

Protein sequence and domain

Belongs to the peptidase M20A family.

Protein cellular localization

Cytoplasm .

Background

CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003

Note

AntibodyPlus can customize CNDP2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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