Rabbit polyclonal CNP antibody (A1018)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CNP antibody (A1018)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CNP antibody, CNPase antibody, CNP1 antibody
2” antibody|2’3′ cyclic nucleotide 3′ phosphodiesterase antibody|3”-cyclic-nucleotide 3”-phosphodiesterase antibody|CN37_HUMAN antibody|CNP 1 antibody|CNP antibody|CNP1 antibody|CNPase antibody|Anti-CNPase antibody [11-5B] (ab6319)

SCBT cat No: sc-22432|

Name

Rabbit polyclonal CNP antibody

Catalogue No.

A1018

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CNP

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 48kDa/Observed: Refer to Figures

Formulation

CNP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CNP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CNP antibody, CNPase antibody, CNP1 antibody

Database links

Human UniProt/Swiss-Prot:P09543

Protein names

CNP, CNPase, CNP1

Protein function

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.

Protein sequence and domain

Belongs to the 2H phosphoesterase superfamily. CNPase family.

Protein cellular localization

Membrane; Lipid-anchor. Melanosome. Note: Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Background

CNPase (2′, 3’-cyclic nucleotide 3′-phosphodiesterase) catalyzes the in vitro hydrolysis of 2’, 3’-cyclic nucleotides to produce 2’-nucleotides. The in vivo molecular function and native substrate of this nucleotide phosphodiesterase remains under investigation (1). High CNPase expression is seen in oligodendrocytes and Schwann cells as CNPase accounts for roughly 4% of the total myelin protein in the central nervous system (2). CNPase binds to tubulin heterodimers and plays a role in tubulin polymerization, and oligodendrocyte process outgrowth (3). Typical myelination is seen in CNPase knock-out mice, but they suffer severe neurodegeneration from axonal loss and oligodendrocytes display abnormal paranodal loop structure prior to axonal degeneration. Paranodal loops typically contact the axolemma in axon-glial signaling; neurodegeneration in CNPase knock-out mice is a secondary consequence of impaired cell-cell communication (4).

Research area

All research areas>Signaling Intermediates>CNPase
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize CNP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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