Rabbit polyclonal COL2A1 antibody (A1560)

$69.00$259.00

Reactivity: Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal COL2A1 antibody (A1560)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal COL2A1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ANFH antibody,AOM antibody,COL11A3 antibody,MGC131516 antibody,SEDC antibody
Alpha 1 type II collagen antibody|Alpha-1 type II collagen antibody|AOM antibody|Cartilage collagen antibody|Chondrocalcin antibody|CO2A1_HUMAN antibody|COL11A3 antibody|Col2a1 antibody|Collagen II alpha 1 polypeptide antibody|SEDC antibody|Anti-Collagen II antibody (ab34712)

SCBT cat No: sc-389924|sc-7763|sc-28887|sc-52658|sc-7764|

Name

Rabbit polyclonal COL2A1 antibody

Catalogue No.

A1560

Reactivity

Mouse

Immunogen

Recombinant protein of human COL2A1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 142kD/Observed: Refer to Figures

Formulation

COL2A1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

COL2A1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ANFH antibody,AOM antibody,COL11A3 antibody,MGC131516 antibody,SEDC antibody

Database links

Human UniProt/Swiss-Prot:P02458

Protein names

ANFH,AOM,COL11A3,MGC131516,SEDC

Protein function

Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

Protein tissue specificity

Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte.

Protein sequence and domain

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).Belongs to the fibrillar collagen family.; Contains 1 fibrillar collagen NC1 domain.; Contains 1 VWFC domain.

Protein post-translational modifications

Probably 3-hydroxylated on prolines by LEPREL1 (By similarity). Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains.; The N-telopeptide is covalently linked to the helical COL2 region of alpha 1(IX), alpha 2(IX) and alpha 3(IX) chain. The C-telopeptide is covalently linked to an another site in the helical region of alpha 3(IX) COL2.

Protein cellular localization

Secreted, extracellular space, extracellular matrix .

Background

This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.

Research area

All research areas>Cell Adhesion Proteins>Collagen
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize COL2A1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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