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Rabbit polyclonal COMT antibody (A6200)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal COMT antibody.
Check alternative names for the antibodyExpand
Catechol O methyltransferase antibody|Catechol O-methyltransferase antibody|COMT antibody|COMT_HUMAN antibody|EC 220.127.116.11 antibody|Anti-COMT antibody [EPR6490] (ab126618)
SCBT cat No: sc-28119|sc-25844|sc-137253|sc-28116|
Rabbit polyclonal COMT antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human COMT
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 30kDa/Observed: Refer to Figures
COMT antibody was tube-contained.
COMT antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
|Protein tissue specificity|| |
Brain, liver, placenta, lymphocytes and erythrocytes.
|Protein sequence and domain|| |
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
|Protein post-translational modifications|| |
The N-terminus is blocked.
|Protein cellular localization|| |
Isoform Soluble: Cytoplasm.; Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side .
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
AntibodyPlus can customize COMT antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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