Rabbit polyclonal COMT antibody (A6200)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal COMT antibody (A6200)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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HEL-S-98n antibody
Catechol O methyltransferase antibody|Catechol O-methyltransferase antibody|COMT antibody|COMT_HUMAN antibody|EC 2.1.1.6 antibody|Anti-COMT antibody [EPR6490] (ab126618)

SCBT cat No: sc-28119|sc-25844|sc-137253|sc-28116|

Name

Rabbit polyclonal COMT antibody

Catalogue No.

A6200

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human COMT

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 30kDa/Observed: Refer to Figures

Formulation

COMT antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

COMT antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HEL-S-98n antibody

Database links

Human UniProt/Swiss-Prot:P21964

Protein names

HEL-S-98n

Protein function

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

Protein tissue specificity

Brain, liver, placenta, lymphocytes and erythrocytes.

Protein sequence and domain

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

Protein post-translational modifications

The N-terminus is blocked.

Protein cellular localization

Isoform Soluble: Cytoplasm.; Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side .

Background

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Research area

All research areas>Signaling Intermediates>COMT
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize COMT antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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