Rabbit polyclonal COPS3 antibody (A7017)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal COPS3 antibody (A7017)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal COPS3 antibody.

Alternative names:

Check alternative names for the antibody

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CSN3 antibody, SGN3 antibody
Constitutive photomorphogenic homolog subunit 3 antibody|COP 9 (constitutive photomorphogenic) subunit 3 antibody|COP 9 complex homolog subunit 3 antibody|COP 9 complex S3 antibody|COP 9 complex subunit 3 antibody|COP 9 constitutive photomorphogenic homolog subunit 3 antibody|COP 9 homolog antibody|COP 9 signalosome complex subunit 3 antibody|COP 9 signalosome subunit 3 antibody|COP 9 subunit 3 antibody|COP9 (constitutive photomorphogenic) subunit 3 antibody|COP9 complex homolog subunit 3 antibody|COP9 complex S3 antibody|COP9 complex subunit 3 antibody|COP9 constitutive photomorphogenic homolog subunit 3 antibody|COP9 homolog antibody|COP9 signalosome complex subunit 3 antibody|COP9 signalosome subunit 3 antibody|COP9 subunit 3 antibody|COPS 3 antibody|cops3 antibody|CSN 3 antibody|CSN3 antibody|CSN3_HUMAN antibody|JAB 1 containing signalosome subunit 3 antibody|JAB1 containing signalosome subunit 3 antibody|JAB1-containing signalosome subunit 3 antibody|SGN 3 antibody|SGN3 antibody|Signalosome subunit 3 antibody|Anti-COPS3 antibody [EPR3127] (ab79698)

SCBT cat No: sc-47961|sc-367529|sc-100693|

Name

Rabbit polyclonal COPS3 antibody

Catalogue No.

A7017

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human COPS3

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 48kDa/Observed: Refer to figures

Formulation

COPS3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

COPS3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CSN3 antibody, SGN3 antibody

Database links

Human UniProt/Swiss-Prot:Q9UNS2

Protein names

CSN3, SGN3

Protein function

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Protein tissue specificity

Widely expressed. Expressed at high level in heart and skeletal muscle.

Protein sequence and domain

Belongs to the CSN3 family.; Contains 1 PCI domain.

Protein cellular localization

Cytoplasm . Nucleus .

Background

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Signaling Intermediates>CSN
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize COPS3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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