Rabbit polyclonal COPS5 antibody (A1766)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal COPS5 antibody (A1766)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CSN5 antibody, JAB1 antibody, MGC3149 antibody, MOV-34 antibody, SGN5 antibody
38 kDa Mov34 homolog antibody|COP9 (constitutive photomorphogenic) homolog subunit 5 antibody|COP9 constitutive photomorphogenic homolog subunit 5 antibody|COP9 signalosome complex subunit 5 antibody|COP9 signalosome subunit 5 antibody|Cop9 subunit 5 antibody|COPS 5 antibody|cops5 antibody|CSN 5 antibody|CSN5 antibody|CSN5_HUMAN antibody|JAB 1 antibody|Jun activation domain binding protein 1 antibody|Jun activation domain binding protein antibody|Jun activation domain-binding protein 1 antibody|MGC3149 antibody|MOV 34 antibody|MOV34 antibody|MOV34 family, 38-KD member antibody|SGN 5 antibody|SGN5 antibody|Signalosome subunit 5 antibody|Anti-JAB1 antibody (ab12323)

SCBT cat No: sc-135954|sc-13157|sc-9074|sc-393725|sc-6271|

Name

Rabbit polyclonal COPS5 antibody

Catalogue No.

A1766

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human COPS5

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 37kDa/Observed: Refer to Figures

Formulation

COPS5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

COPS5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CSN5 antibody, JAB1 antibody, MGC3149 antibody, MOV-34 antibody, SGN5 antibody

Database links

Human UniProt/Swiss-Prot:Q92905

Protein names

CSN5, JAB1, MGC3149, MOV-34, SGN5

Protein function

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

Protein sequence and domain

The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).Belongs to the peptidase M67A family. CSN5 subfamily.; Contains 1 MPN (JAB/Mov34) domain.

Protein cellular localization

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note: Nuclear localization is diminished in the presence of IFIT3.

Background

The COP9 Signalosome (CSN) is a ubiquitously expressed multiprotein complex that is involved in a vast array of cellular and developmental processes, which is thought to be attributed to its control over the ubiquitin-proteasome pathway. Typically, the CSN is composed of eight highly conserved subunits (CSN1-CSN8), each of which is homologous to one of the eight subunits that form the lid of the 26S proteasome particle, suggesting that these complexes have a common evolutionary ancestor (1). CSN was first identified in Arabidopsis thaliana mutants with a light-grown seedling phenotype when grown in the dark (2-4). The subsequent cloning of the constitutive morphogenesis 9 (cop9) mutant from Arabidopsis thaliana was soon followed by the biochemical purification of the COP9-containing multiprotein complex (4). It is now widely accepted that the CSN directly interacts with cullin-RING ligase (CRL) families of ubiquitin E3 complexes, and that CSN is required for their proper function (5). In addition, CSN may also regulate protein homeostasis through its association with protein kinases and deubiquitinating enzymes. Collectively, these activities position the CSN as a pivotal regulator of the DNA-damage response, cell-cycle control, and gene expression (1).COPS5/CSN5/Jab1 (c-Jun activation domain-binding protein-1) was originally identified as a transcriptional coactivator of c-Jun and subsequently discovered to be a fifth component and integral part of the CSN (6). As the catalytic center of the CSN, COPS5 is able to integrate multiple functions of the CSN complex such as cell-cycle control, transcription, and DNA-damage response by regulating the activity of CRLs through deneddylation of cullins (7).

Research area

All research areas>Transcription Regulators>JAB1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize COPS5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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