Rabbit polyclonal COPS7A antibody (A8212)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal COPS7A antibody (A8212)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal COPS7A antibody.

Alternative names:

Check alternative names for the antibody

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CSN7 antibody, CSN7A antibody, SGN7a antibody
COP9 complex subunit 7a antibody|COP9 constitutive photomorphogenic homolog subunit 7A antibody|COP9 signalosome complex subunit 7a antibody|COP9 signalosome subunit 7A antibody|COPS7A antibody|CSN7A antibody|CSN7A_HUMAN antibody|Dermal papilla derived protein 10 antibody|Dermal papilla-derived protein 10 antibody|DERP10 antibody|JAB1 containing signalosome subunit 7a antibody|JAB1-containing signalosome subunit 7a antibody|SGN7a antibody|Signalosome subunit 7a antibody|Anti-COPS7A antibody (ab192381)

SCBT cat No: sc-398882|sc-514067|sc-367016|sc-47971|

Name

Rabbit polyclonal COPS7A antibody

Catalogue No.

A8212

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human COPS7A

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 30kDa/Observed: Refer to figures

Formulation

COPS7A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

COPS7A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CSN7 antibody, CSN7A antibody, SGN7a antibody

Database links

Human UniProt/Swiss-Prot:Q9UBW8

Protein names

CSN7, CSN7A, SGN7a

Protein function

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Protein tissue specificity

Widely expressed. Expressed at high level in brain, heart and skeletal muscle.

Protein sequence and domain

Belongs to the CSN7/EIF3M family. CSN7 subfamily.; Contains 1 PCI domain.

Protein post-translational modifications

Phosphorylated by CK2 and PKD kinases.

Protein cellular localization

Cytoplasm . Nucleus .

Background

This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described.

Research area

All research areas>Signaling Intermediates>CSN
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize COPS7A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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