Rabbit Polyclonal CORO1A antibody (A9300)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal CORO1A antibody (A9300)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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p57 antibody; IMD8 antibody; TACO antibody; CLABP antibody; HCORO1 antibody; CLIPINA
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SCBT cat No:

Name

Rabbit Polyclonal CORO1A antibody

Catalogue No.

A9300

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CORO1A

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

51kDa

Formulation

CORO1A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

p57 antibody; IMD8 antibody; TACO antibody; CLABP antibody; HCORO1 antibody; CLIPINA

Protein names

p57; IMD8; TACO; CLABP; HCORO1; CLIPINA

Protein function

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

Protein tissue specificity

Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

Protein sequence and domain

Belongs to the WD repeat coronin family.; Contains 7 WD repeats.

Protein post-translational modifications

phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.; Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.

Protein cellular localization

Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Cytoplasmic vesicle, phagosome membrane . Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).

Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16.

Note

AntibodyPlus can customize CORO1A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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