Rabbit polyclonal CPSF3L antibody (A6566)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CPSF3L antibody (A6566)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CPSF3L antibody.

Alternative names:

Check alternative names for the antibody

Expand

RC68 antibody, INT11 antibody, RC-68 antibody, INTS11 antibody, CPSF73L antibody
2410006F12Rik antibody|RGD1306841 antibody|RP23 242K15.19 antibody|Anti-INT11 antibody (ab75276)

SCBT cat No:

Name

Rabbit polyclonal CPSF3L antibody

Catalogue No.

A6566

Reactivity

Human

Immunogen

Recombinant protein of human CPSF3L

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 67kDa/Observed: Refer to figures

Formulation

CPSF3L antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CPSF3L antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RC68 antibody, INT11 antibody, RC-68 antibody, INTS11 antibody, CPSF73L antibody

Database links

Human UniProt/Swiss-Prot:Q5TA45

Protein names

RC68, INT11, RC-68, INTS11, CPSF73L

Protein function

Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3′-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3′ cleavage.

Protein sequence and domain

The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.

Protein cellular localization

Nucleus . Cytoplasm .

Background

The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005

Note

AntibodyPlus can customize CPSF3L antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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