Rabbit polyclonal CREB1 antibody (A1189)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal CREB1 antibody (A1189)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CREB1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

CREB1 antibody,CREB antibody,MGC9284 antibody
Active transcription factor CREB antibody|Extracellular signal-regulated kinase 2 antibody|HS44KDAP antibody|HUMKER1A antibody|Insulin stimulated MAP2 kinase antibody|MAP kinase 1 antibody|MAP kinase 2 antibody|MAP kinase 3 antibody|MAP kinase isoform p42 antibody|MAP kinase isoform p44 antibody|MAPK 1 antibody|MAPK 2 antibody|Mapk1 antibody|MAPK2 antibody|MAPK3 antibody|Microtubule associated protein 2 kinase antibody|Mitogen activated protein kinase 3 antibody|Mitogen-activated protein kinase 1 antibody|Mitogen-activated protein kinase 2 antibody|MK01_HUMAN antibody|p38 antibody|p40 antibody|p41 antibody|p41mapk antibody|p42-MAPK antibody|P42MAPK antibody|p44 ERK1 antibody|p44 MAPK antibody|P44ERK1 antibody|P44MAPK antibody|PRKM1 antibody|PRKM2 antibody|PRKM3 antibody|Protein tyrosine kinase ERK2 antibody|Transactivator protein antibody|Phospho anti-CREB (S133) antibody [E113] (ab32096)

SCBT cat No: sc-58|sc-271|sc-186|sc-377154|sc-374227|sc-25785|sc-240|sc-390063|sc-7583|

Name

Rabbit polyclonal CREB1 antibody

Catalogue No.

A1189

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CREB1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 35kDa/Observed: Refer to Figures

Formulation

CREB1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CREB1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CREB1 antibody,CREB antibody,MGC9284 antibody

Database links

Human UniProt/Swiss-Prot:P16220

Protein names

CREB1,CREB,MGC9284

Protein function

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Protein sequence and domain

Belongs to the bZIP family.; Contains 1 bZIP (basic-leucine zipper) domain.; Contains 1 KID (kinase-inducible) domain.

Protein post-translational modifications

Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.; Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.

Protein cellular localization

Nucleus .

Background

CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations (1-3). Additionally, CREB signaling is involved in learning and memory in several organisms (4-6). CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2 (7-9).

Research area

All research areas>Transcription Regulators>CREB
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize CREB1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!