Rabbit polyclonal CRHR1 antibody (A8409)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CRHR1 antibody (A8409)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CRHR1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

CRF1 antibody, CRHR antibody, CRF-R antibody, CRFR1 antibody, CRF-R1 antibody, CRFR-1 antibody, CRH-R1 antibody, CRHR1L antibody, CRF-R-1 antibody, CRH-R-1 antibody
Corticotropin releasing factor type 1 receptor antibody|corticotropin releasing hormone receptor 1 antibody|Corticotropin-releasing factor receptor 1 antibody|Corticotropin-releasing hormone receptor 1 antibody|CRF R antibody|crf receptor 1 antibody|crf receptor type 1 antibody|crf type 1 antibody|CRF-R antibody|CRF-R-1 antibody|CRF-R1 antibody|CRF1 antibody|CRFR antibody|CRFR-1 antibody|CRFR1 antibody|CRFR1_HUMAN antibody|CRH-R-1 antibody|CRH-R1 antibody|CRH-R1h antibody|CRHR antibody|Crhr1 antibody|CRHR1f antibody|CRHR1L antibody|Anti-CRF1 antibody (ab59023)

SCBT cat No: sc-12383|sc-12381|sc-1757|sc-5543|

Name

Rabbit polyclonal CRHR1 antibody

Catalogue No.

A8409

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CRHR1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 51kDa/Observed: Refer to figures

Formulation

CRHR1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CRHR1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CRF1 antibody, CRHR antibody, CRF-R antibody, CRFR1 antibody, CRF-R1 antibody, CRFR-1 antibody, CRH-R1 antibody, CRHR1L antibody, CRF-R-1 antibody, CRH-R-1 antibody

Database links

Human UniProt/Swiss-Prot:P34998

Protein names

CRF1, CRHR, CRF-R, CRFR1, CRF-R1, CRFR-1, CRH-R1, CRHR1L, CRF-R-1, CRH-R-1

Protein function

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Protein tissue specificity

Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.

Protein sequence and domain

The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure. The antagonist CP-376395 binds at an allosteric site, far from the presumed binding site for the physiological peptide ligand.Belongs to the G-protein coupled receptor 2 family.

Protein post-translational modifications

C-terminal Ser or Thr residues may be phosphorylated.; Phosphorylation at Ser-330 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling.

Protein cellular localization

Cell membrane; Multi-pass membrane protein. Endosome. Note: Agonist-binding promotes endocytosis.

Background

This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and upstream GeneID:401884 (ADP-ribosylation factor 3 pseudogene), and the readthrough transcripts encode isoforms that share similarity with the products of this gene.

Research area

All research areas>Neurobiology>CRF-R
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize CRHR1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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