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Rabbit polyclonal CRK antibody (A1604)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal CRK antibody.
Check alternative names for the antibodyExpand
p38 antibody, CRKII antibody
Adapter molecule crk antibody|Avian sarcoma virus CT10 (v crk) oncogene homolog antibody|CRK antibody|CRK isoform 2 antibody|CRK isoform II antibody|CRK_HUMAN antibody|CRKII antibody|FLJ38130 antibody|OTTHUMP00000115366 antibody|OTTHUMP00000198330 antibody|p38 antibody|Proto oncogene C crk antibody|Proto-oncogene C-crk antibody|v crk avian sarcoma virus CT10 oncogene homolog antibody|v crk sarcoma virus CT10 oncogene homolog antibody|v crk sarcoma virus CT10 oncogene homolog (avian) antibody|Anti-Crk p38 antibody [EPR4984(2)] (ab133581)
SCBT cat No: sc-393160|sc-23775|sc-17989|sc-81234|sc-390132|sc-289|sc-9004|
Rabbit polyclonal CRK antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human CRK
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 34kDa/Observed: Refer to figures
CRK antibody was tube-contained.
CRK antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
p38 antibody, CRKII antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
|Protein sequence and domain|| |
The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation.; The SH2 domain mediates interaction with tyrosine phosphorylated proteins. Mediates interaction with SHB.Belongs to the CRK family.; Contains 1 SH2 domain.; Contains 2 SH3 domains.
|Protein post-translational modifications|| |
Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form. Isoform Crk-II is phosphorylated by KIT.; Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway.; Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form.
|Protein cellular localization|| |
Cytoplasm . Cell membrane . Note: Translocated to the plasma membrane upon cell adhesion.
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
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|Product type|| |
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