Rabbit Polyclonal CSE1L antibody (A9510)

$99.00$259.00

Reactivity: Human
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal CSE1L antibody (A9510)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

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Alternative names:

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CAS antibody|Cellular apoptosis susceptibility protein antibody|Chromosome segregation 1 (yeast homolog) like antibody|Chromosome segregation 1 Like antibody|Chromosome segregation 1 like protein antibody|Chromosome segregation 1-like protein antibody|Chromosome segregation gene CSE1 antibody|CSE 1 antibody|CSE 1 chromosome segregation 1 like antibody|CSE 1 chromosome segregation 1 like protein antibody|CSE 1L antibody|CSE1 antibody|CSE1 chromosome segregation 1 like (yeast) antibody|CSE1 chromosome segregation 1 like antibody|CSE1 chromosome segregation 1 like protein antibody|CSE1L antibody|Exp 2 antibody|Exp2 antibody|Exportin 2 antibody|Exportin-2 antibody|Exportin2 antibody|Importin alpha re exporter antibody|Importin-alpha re-exporter antibody|MGC117283 antibody|MGC130036 antibody|MGC130037 antibody|XPO 2 antibody|XPO2 antibody|XPO2_HUMAN antibody|Anti-Cellular Apoptosis Susceptibility antibody [EPR10327(B)] (ab151546)

SCBT cat No: sc-135855|sc-1708|sc-271537|sc-28233|sc-1709|

Name

Rabbit Polyclonal CSE1L antibody

Catalogue No.

A9510

Reactivity

Human

Immunogen

A synthetic peptide of human CSE1L

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

110kDa

Formulation

CSE1L antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Protein function

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Protein tissue specificity

Highly expressed in proliferating cells.

Protein sequence and domain

Belongs to the XPO2/CSE1 family.; Contains 1 importin N-terminal domain.

Protein cellular localization

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.

Background

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Tumor-SuppressorApoptosis/">Tumor Suppressor/Apoptosis</a>><a href="http://antibodyplus.com/product-tag/CAS/">CAS</a><br><a href="http://antibodyplus.com/product-tag/Tumor-SuppressorApoptosis/"&gt; (View all antibody categories related to Tumor Suppressor/Apoptosis)</a>

Note

AntibodyPlus can customize CSE1L antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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