Rabbit polyclonal CSF1R antibody (A3019)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CSF1R antibody (A3019)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CSF1R antibody.

Alternative names:

Check alternative names for the antibody

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FMS antibody, CSFR antibody, FIM2 antibody, HDLS antibody, C-FMS antibody, CD115 antibody, CSF-1R antibody, M-CSF-R antibody
C FMS antibody|CD 115 antibody|CD115 antibody|CD115 antigen antibody|CFMS antibody|Colony stimulating factor 1 receptor antibody|Colony stimulating factor I receptor antibody|CSF 1 R antibody|CSF 1R antibody|CSF-1 receptor antibody|CSF-1-R antibody|CSF1 R antibody|CSF1R antibody|CSF1R_HUMAN antibody|CSFR antibody|EC 2.7.10.1 antibody|FIM 2 antibody|FIM2 antibody|FMS antibody|FMS proto oncogene antibody|FMS protooncogene antibody|HDLS antibody|M-CSF Receptor antibody|M-CSF-R antibody|Macrophage colony stimulating factor 1 receptor antibody|Macrophage colony stimulating factor I receptor antibody|Macrophage colony-stimulating factor 1 receptor antibody|McDonough feline sarcoma viral (v fms) oncogene homolog antibody|MCSFR antibody|Oncogen FMS antibody|Proto-oncogene c-Fms antibody|V-FMS McDonough feline sarcoma viral oncogen homolog, formerly antibody|Anti-MCSF Receptor antibody [SP211] (ab183316)

SCBT cat No: sc-70451|sc-70453|sc-01|sc-02|sc-57047|sc-70452|sc-46662|sc-692|sc-365719|sc-31638|sc-13949|sc-52|sc-413|

Name

Rabbit polyclonal CSF1R antibody

Catalogue No.

A3019

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human CSF1R

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 108kDa/Observed: Refer to Figures

Formulation

CSF1R antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CSF1R antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FMS antibody, CSFR antibody, FIM2 antibody, HDLS antibody, C-FMS antibody, CD115 antibody, CSF-1R antibody, M-CSF-R antibody

Database links

Human UniProt/Swiss-Prot:P07333

Protein names

FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R

Protein function

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.

Protein tissue specificity

Expressed in bone marrow and in differentiated blood mononuclear cells.

Protein sequence and domain

The juxtamembrane domain functions as autoinhibitory region. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase.; The activation loop plays an important role in the regulation of kinase activity. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase.Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.; Contains 5 Ig-like C2-type (immunoglobulin-like) domains.; Contains 1 protein kinase domain.

Protein post-translational modifications

Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-561 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-561 and Tyr-809 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-699 and Tyr-923 is important for interaction with GRB2. Phosphorylation at Tyr-723 is important for interaction with PIK3R1. Phosphorylation at Tyr-708 is important for normal receptor degradation. Phosphorylation at Tyr-723 and Tyr-809 is important for interaction with PLCG2. Phosphorylation at Tyr-969 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation.; Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation.

Protein cellular localization

Cell membrane; Single-pass type I membrane protein.

Background

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.

Research area

All research areas>Membrane Receptors>c-Fms-CSF-1R
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize CSF1R antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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