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Rabbit polyclonal CSK antibody (A0735)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:200 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal CSK antibody.
Check alternative names for the antibodyExpand
C SRC antibody|C SRC kinase antibody|C src Tyrosine Kinase antibody|C-SRC kinase antibody|c-src tyrosine kinase antibody|Csk A antibody|CSK antibody|CSK_HUMAN antibody|CYTOPLASMIC TYROSINE KINASE antibody|EC 18.104.22.168 antibody|MGC112926 antibody|MGC117393 antibody|MGC154049 antibody|P60 Src antibody|Protein tyrosine kinase CYL antibody|Protein-tyrosine kinase CYL antibody|Proto oncogene tyrosine protein kinase antibody|Tyrosine protein kinase CSK antibody|Tyrosine-protein kinase CSK antibody|zgc:154049 antibody|Anti-CSK antibody (ab744)
SCBT cat No: sc-166513|sc-286|sc-51580|sc-166560|sc-13074|sc-9897|
Rabbit polyclonal CSK antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human CSK
|Recommended dilution|| |
WB 1:200 – 1:2000
|Molecular weight|| |
Predicted: 50kDa/Observed: Refer to Figures
CSK antibody was tube-contained.
CSK antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
|Protein tissue specificity|| |
Expressed in lung and macrophages.
|Protein sequence and domain|| |
The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain.Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.; Contains 1 protein kinase domain.; Contains 1 SH2 domain.; Contains 1 SH3 domain.
|Protein post-translational modifications|| |
Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.
|Protein cellular localization|| |
Cytoplasm . Cell membrane . Note: Mainly cytoplasmic, also present in lipid rafts.
CSK(Tyrosine-protein kinase CSK) is also named as C-Src kinase, protein-tyrosine kinase CYL and belongs to the protein kinase superfamily. Csk is a non-receptor tyrosine kinase with a molecular mass of 50 kDa. It contains the SH3 and SH2 domains in its N-terminus and a kinase domain in its C-terminus. It negatively regulates the kinase activity of SFKs and plays an important role in physiological functions via signaling pathways for cell proliferation, differentiation, adhesion, and migration(PMID:23548896). Csk may play a role in tumor suppression by inhibiting the oncogenic activity of SFKs. Indeed, overexpression of Csk can inhibit tumor growth of human colon cancer cells(PMID:23139636). This protein can be autophosphorylated(PMID:11181701). This antibody is specific to CSK.
AntibodyPlus can customize CSK antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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