Rabbit polyclonal CSNK2A1 antibody (A1014)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CSNK2A1 antibody (A1014)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:4000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CSNK2A1 antibody,CK2A1 antibody,CKII antibody
Casein kinase 2 alpha 1 polypeptide antibody|Casein kinase II alpha 1 antibody|Casein kinase II alpha 1 subunit antibody|Casein kinase II alpha subunit antibody|Casein kinase II subunit alpha antibody|CK II alpha antibody|CK II antibody|CK2 alpha antibody|CK2 catalytic subunit alpha antibody|CK2A1 antibody|CKII antibody|CKIIalpha antibody|CSK21_HUMAN antibody|CSNK2A1 antibody|Anti-CKII alpha antibody [8E5] – ChIP Grade (ab70774)

SCBT cat No: sc-12738|sc-6479|sc-365762|sc-365787|sc-373894|sc-365763|sc-9030|sc-6481|

Name

Rabbit polyclonal CSNK2A1 antibody

Catalogue No.

A1014

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CSNK2A1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:1000 – 1:4000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to Figures

Formulation

CSNK2A1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CSNK2A1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CSNK2A1 antibody,CK2A1 antibody,CKII antibody

Database links

Human UniProt/Swiss-Prot:P68400

Protein names

CSNK2A1,CK2A1,CKII

Protein function

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating ‘Ser-392’ of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at ‘Ser-565’ and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at ‘Ser-90’ which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry . Phosphorylates CCAR2 at ‘Thr-454’ in gastric carcinoma tissue .

Protein tissue specificity

Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level).

Protein sequence and domain

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.; Contains 1 protein kinase domain.

Protein post-translational modifications

Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments.

Protein cellular localization

Nucleus .

Background

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

Research area

All research areas>Kinases and Phosphatases>Casein Kinase
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize CSNK2A1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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