Rabbit polyclonal CTNND1 antibody (A1641)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,ICC,IF,IP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal CTNND1 antibody (A1641)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,ICC,IF,IP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 ICC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CTNND1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

CAS antibody, CTNND antibody, KIAA0384 antibody, P120CAS antibody, P120CTN antibody, p120 antibody
Cadherin associated Src substrate antibody|Cadherin-associated Src substrate antibody|CAS antibody|Catenin (cadherin associated protein) delta 1 antibody|Catenin delta 1 antibody|Catenin delta antibody|Catenin delta-1 antibody|CTND1_HUMAN antibody|CTNND 1 antibody|CTNND antibody|CTNND1 antibody|KIAA0384 antibody|p120 antibody|P120 CAS antibody|p120 catenin antibody|P120 CTN antibody|p120(cas) antibody|p120(ctn) antibody|P120CAS antibody|P120CTN antibody|Anti-delta 1 Catenin antibody [EPR357(2)] (ab92514)

SCBT cat No: sc-1101|

Name

Rabbit polyclonal CTNND1 antibody

Catalogue No.

A1641

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CTNND1

Host

Rabbit

Applications

WB, IHC, ICC, IF, IP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
ICC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 105kDa/Observed: Refer to Figures

Formulation

CTNND1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CTNND1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CAS antibody, CTNND antibody, KIAA0384 antibody, P120CAS antibody, P120CTN antibody, p120 antibody

Database links

Human UniProt/Swiss-Prot:O60716

Protein names

CAS, CTNND, KIAA0384, P120CAS, P120CTN, p120

Protein function

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Protein tissue specificity

Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.

Protein sequence and domain

A possible nuclear localization signal exists in all isoforms where Asp-626–631-Arg are deleted.; ARM repeats 1 to 5 mediate interaction with cadherins.Belongs to the beta-catenin family.; Contains 10 ARM repeats.

Protein post-translational modifications

Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ.

Protein cellular localization

Cytoplasm. Nucleus. Cell membrane. Note: Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excluded from the nucleus.; Isoform 1A: Nucleus.; Isoform 2A: Nucleus.; Isoform 3A: Nucleus.

Background

Catenin delta-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function (1). Catenin delta-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin delta-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin delta-1, which modulates RhoA, Rac, and cdc42 proteins (1). Analogous to beta-catenin, catenin delta-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin delta-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin delta-1 may function as a tumor suppressor (4).Phosphorylation of Tyr904 on Catenin-delta-1 was identified at Cell Signaling Technology (CST) using PhosphoScan®, a CST’s LC-MS/MS platform for phosphorylation site discovery (5).

Research area

All research areas>Cell Adhesion Proteins>p120
(View all antibody categories related to Cell Adhesion Proteins)

Note

AntibodyPlus can customize CTNND1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!