Rabbit polyclonal CTSC antibody (A8403)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal CTSC antibody (A8403)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CTSC antibody.

Alternative names:

Check alternative names for the antibody

Expand

JP antibody, HMS antibody, JPD antibody, PLS antibody, CPPI antibody, DPP1 antibody, DPPI antibody, PALS antibody, DPP-I antibody, PDON1 antibody
AI047818 antibody|CATC antibody|CATC_HUMAN antibody|Cathepsin C antibody|Cathepsin J antibody|CPPI antibody|CTSC antibody|Dipeptidyl peptidase 1 antibody|Dipeptidyl peptidase 1 light chain antibody|Dipeptidyl peptidase I antibody|Dipeptidyl peptidase I exclusion domain chain antibody|Dipeptidyl peptidase I heavy chain antibody|Dipeptidyl peptidase I light chain antibody|Dipeptidyl transferase antibody|DPP I antibody|DPP-I antibody|DPPI antibody|EC 3.4.14.1 antibody|HMS antibody|JP antibody|JPD antibody|MGC126959 antibody|PALS antibody|PDON1 antibody|PLS antibody|Anti-DPP1 antibody [EPR7749] – C-terminal (ab192019)

SCBT cat No: sc-74590|sc-13986|sc-5647|

Name

Rabbit polyclonal CTSC antibody

Catalogue No.

A8403

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CTSC

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to figures

Formulation

CTSC antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CTSC antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

JP antibody, HMS antibody, JPD antibody, PLS antibody, CPPI antibody, DPP1 antibody, DPPI antibody, PALS antibody, DPP-I antibody, PDON1 antibody

Database links

Human UniProt/Swiss-Prot:P53634

Protein names

JP, HMS, JPD, PLS, CPPI, DPP1, DPPI, PALS, DPP-I, PDON1

Protein function

Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.

Protein tissue specificity

Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.

Protein sequence and domain

Belongs to the peptidase C1 family.

Protein post-translational modifications

N-glycosylated. While glycosylation at Asn-53, Asn-119 and Asn-276 is mediated by STT3A-containing complexes, glycosylation at Asn-29 is mediated STT3B-containing complexes.; In approximately 50% of the complexes the exclusion domain is cleaved at position 58 or 61. The two parts of the exclusion domain are held together by a disulfide bond.

Protein cellular localization

Lysosome.

Background

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Synthesis and Degradation>Cathepsin
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize CTSC antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!