Rabbit polyclonal CTSK antibody (A1782)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CTSK antibody (A1782)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

CTS02 antibody, CTSO antibody, CTSO1 antibody, CTSO2 antibody, MGC23107 antibody, PKND antibody, PYCD antibody
Cathepsin K antibody|Cathepsin O antibody|Cathepsin O2 antibody|Cathepsin X antibody|CATK_HUMAN antibody|Ctsk antibody|CTSW antibody|Lymphopain antibody|LYPN antibody|Anti-Cathepsin K antibody (ab19027)

SCBT cat No: sc-6506|sc-48353|sc-30056|sc-6507|sc-135859|sc-32320|sc-393770|

Name

Rabbit polyclonal CTSK antibody

Catalogue No.

A1782

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CTSK

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 39kDa/Observed: Refer to Figures

Formulation

CTSK antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CTSK antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CTS02 antibody, CTSO antibody, CTSO1 antibody, CTSO2 antibody, MGC23107 antibody, PKND antibody, PYCD antibody

Database links

Human UniProt/Swiss-Prot:P43235

Protein names

CTS02, CTSO, CTSO1, CTSO2, MGC23107, PKND, PYCD

Protein function

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

Protein tissue specificity

Predominantly expressed in osteoclasts (bones).

Protein sequence and domain

Belongs to the peptidase C1 family.

Protein cellular localization

Lysosome.

Background

CTSK(cathepsin K), also named as CTSO, CTSO2, is a recently identified lysosomal cysteine proteinase. CTSK is synthesized as a proenzyme of 38 kDa and subsequently enters acidic lysosomal compartments, in which the propeptide is cleaved and transformed into an active enzyme and it may influence adipocyte differentiation through modifying extracellular matrix components(PMID:16912123). It is revealed both the 46-kDa cathepsin-K precursor and the 30-kDa mature form in mouse bone extracts(PMID:9811821). The high CTSK protein levels are only detected in primary cultured fibroblasts derived from normal and neoplastic breast tissue, where the 37- and 25-kDa bands to be detected correspond to pro- and mature proteins through western blot(PMID:18765527). The full length protein has a signal peptides with 15 amino acids and a propeptide with 99 amino acids. This antibody is specific to CTSK.

Research area

All research areas>Synthesis and Degradation>Cathepsin
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize CTSK antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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