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Rabbit polyclonal CUL2 antibody (A5308)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal CUL2 antibody.
Check alternative names for the antibodyExpand
Cul2 antibody|CUL 2 antibody|CUL-2 antibody|CUL2 antibody|CUL2_HUMAN antibody|cullin 2 antibody|cullin homolog 2 antibody|Cullin-2 antibody|MGC131970 antibody|Anti-Cullin 2 antibody – C-terminal (ab166823)
SCBT cat No: sc-166506|
Rabbit polyclonal CUL2 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human CUL2
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 87kDa/Observed: Refer to Figures
CUL2 antibody was tube-contained.
CUL2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
|Protein sequence and domain|| |
Belongs to the cullin family.
|Protein post-translational modifications|| |
CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity).
CUL2 is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. It serves as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
AntibodyPlus can customize CUL2 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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