Rabbit polyclonal CXADR antibody (A1822)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CXADR antibody (A1822)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CAR antibody, HCAR antibody, CAR4/6 antibody
46 kD coxsackievirus and adenovirus receptor CAR protein antibody|46 kD coxsackievirus and adenovirus receptor protein antibody|CAR antibody|CAR4/6 antibody|Coxsackie virus and adenovirus receptor antibody|Coxsackie virus B receptor antibody|Coxsackievirus and adenovirus receptor antibody|Coxsackievirus B adenovirus receptor antibody|Coxsackievirus B-adenovirus receptor antibody|CVB3 binding protein antibody|CVB3-binding protein antibody|Cxadr antibody|CXAR_HUMAN antibody|hCAR antibody|HCVADR antibody|Anti-Coxsackie Adenovirus Receptor antibody (ab153740)

SCBT cat No: sc-70493|sc-365836|sc-373791|sc-56892|sc-15405|sc-32795|sc-10313|

Name

Rabbit polyclonal CXADR antibody

Catalogue No.

A1822

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CXADR

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 40kDa/Observed: Refer to Figures

Formulation

CXADR antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CXADR antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CAR antibody, HCAR antibody, CAR4/6 antibody

Database links

Human UniProt/Swiss-Prot:P78310

Protein names

CAR, HCAR, CAR4/6

Protein function

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.; (Microbial infection) Acts as a receptor for adenovirus type C . Acts as a receptor for Coxsackievirus B1 to B6 .

Protein tissue specificity

Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.

Protein sequence and domain

The Ig-like C2-type 1 domain mediates homodimerization and interaction with JAML.; The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Protein post-translational modifications

N-glycosylated.; Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.

Protein cellular localization

Isoform 1: Cell membrane ; Single-pass type I membrane protein . Basolateral cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction . Cell junction, adherens junction . Note: In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions . In airway epithelial cells localized to basolateral membrane but not to apical surface .; Isoform 3: Secreted .; Isoform 4: Secreted .; Isoform 5: Secreted .

Background

The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.

Research area

All research areas>Membrane Receptors>Coxsackie & Adenovirus Receptor
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize CXADR antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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