Rabbit polyclonal CXCR3 antibody (A2939)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CXCR3 antibody (A2939)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

GPR9 antibody,MigR antibody,CD182 antibody,CD183 antibody,Mig-R antibody,CKR-L2 antibody,CMKAR3 antibody,IP10-R antibody
C-X-C chemokine receptor type 3 antibody|CD 183 antibody|CD182 antibody|CD183 antibody|Chemokine (C X C motif) receptor 3 antibody|Chemokine (C X C) receptor 3 antibody|Chemokine CXC Motif Receptor 3 antibody|CKR L2 antibody|CKR-L2 antibody|CKRL2 antibody|CMKAR3 antibody|CXC-R3 antibody|CXCR-3 antibody|CXCR3 antibody|CXCR3_HUMAN antibody|G Protein Coupled Receptor 9 antibody|G protein-coupled receptor 9 antibody|GPR9 antibody|Interferon-inducible protein 10 receptor antibody|IP-10 receptor antibody|IP10 antibody|IP10 R antibody|IP10 receptor antibody|IP10-R antibody|IP10R antibody|Mig R antibody|Mig receptor antibody|Mig-R antibody|MIGR antibody|Anti-CXCR3 antibody [2Ar1] (ab64714)

SCBT cat No: sc-6226|sc-137140|sc-133087|sc-133121|sc-13951|sc-9901|

Name

Rabbit polyclonal CXCR3 antibody

Catalogue No.

A2939

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human CXCR3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 46kDa/Observed: Refer to Figures

Formulation

CXCR3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CXCR3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GPR9 antibody,MigR antibody,CD182 antibody,CD183 antibody,Mig-R antibody,CKR-L2 antibody,CMKAR3 antibody,IP10-R antibody

Database links

Human UniProt/Swiss-Prot:P49682

Protein names

GPR9,MigR,CD182,CD183,Mig-R,CKR-L2,CMKAR3,IP10-R

Protein function

Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway . Binds to CCL21. Probably promotes cell chemotaxis response.; Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway . Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.; Isoform 3: Mediates the activity of CXCL11.

Protein tissue specificity

Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level).

Protein sequence and domain

Belongs to the G-protein coupled receptor 1 family.

Protein post-translational modifications

Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.; N-glycosylated.

Protein cellular localization

Isoform 1: Cell membrane ; Multi-pass membrane protein .; Isoform 2: Cell membrane ; Multi-pass membrane protein .

Background

The neuronal growth-associated protein GAP43 is also known as neuromodulin, B-50, P-57, F1 and pp46. Deficiency of GAP43 in mice results in death early in the postnatal period. GAP43 is one of the main substrates for protein kinase C in the brain. GAP43 is an intracellular growth-associated protein that appears to assist neuronal pathfinding and branching during development and regeneration, and may contribute to presynaptic membrane changes in the adult, leading to the neurotransmitter release, endocytosis and synaptic vesicle recycling, long-term potentiation, spatial memory formation, and learning. The predicated molecular weight of about 25 kDa is much lower than the apparent observed molecular weight of 43 kDa on SDS-PAGE gels, and this occurs because the highly charged nature of GAP43 causes it to bind less than the average amount of SDS per amino acid, and because the protein has an elongated structure.

Research area

All research areas>Membrane Receptors>CXCR-3
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize CXCR3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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