Rabbit polyclonal CYBB antibody (A1636)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CYBB antibody (A1636)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CYBB antibody.

Alternative names:

Check alternative names for the antibody

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CGD antibody, GP91-1 antibody, GP91-PHOX antibody, GP91PHOX antibody, NOX2 antibody, p91-PHOX antibody
AMCBX2 antibody|CGD antibody|CGD91-phox antibody|CY24B_HUMAN antibody|CYBB antibody|Cytochrome b 245, beta polypeptide antibody|Cytochrome b(558) beta chain antibody|Cytochrome b(558) subunit beta antibody|Cytochrome b-245 heavy chain antibody|Cytochrome b558 subunit beta antibody|GP91 PHOX antibody|gp91-1 antibody|gp91-phox antibody|GP91PHOX antibody|Heme-binding membrane glycoprotein gp91phox antibody|NADPH oxidase 2 antibody|Neutrophil cytochrome b 91 kDa polypeptide antibody|NOX2 antibody|p22 phagocyte B-cytochrome antibody|P91 PHOX antibody|p91-PHOX antibody|Superoxide-generating NADPH oxidase heavy chain subunit antibody|Anti-NOX2/gp91phox antibody (ab80508)

SCBT cat No: sc-130543|sc-5827|sc-130549|sc-27635|sc-74514|sc-20782|sc-5826|sc-130548|

Name

Rabbit polyclonal CYBB antibody

Catalogue No.

A1636

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CYBB

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 65kDa/Observed: Refer to Figures

Formulation

CYBB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CYBB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CGD antibody, GP91-1 antibody, GP91-PHOX antibody, GP91PHOX antibody, NOX2 antibody, p91-PHOX antibody

Database links

Human UniProt/Swiss-Prot:P04839

Protein names

CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX

Protein function

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.

Protein tissue specificity

Detected in neutrophils (at protein level).

Protein sequence and domain

Contains 1 FAD-binding FR-type domain.; Contains 1 ferric oxidoreductase domain.

Protein post-translational modifications

Glycosylated.; Phosphorylated on Ser and Thr residues.

Protein cellular localization

Cell membrane; Multi-pass membrane protein.

Background

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell’s respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

Research area

All research areas>Synthesis and Degradation>gp91-phox
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize CYBB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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