Rabbit polyclonal CYCS antibody (A0225)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal CYCS antibody (A0225)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:1000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal CYCS antibody.

Alternative names:

Check alternative names for the antibody

Expand

CYCS antibody,CYC antibody,HCS antibody,THC4 antibody
CYC antibody|CYC_HUMAN antibody|CYCS antibody|Cytochrome c antibody|Cytochrome c somatic antibody|HCS antibody|THC4 antibody|Anti-Cytochrome C antibody [7H8.2C12] (ab13575)

SCBT cat No: sc-65396|sc-13561|sc-13560|sc-13156|sc-8385|sc-7159|

Name

Rabbit polyclonal CYCS antibody

Catalogue No.

A0225

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human CYCS

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:1000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 12kDa/Observed: Refer to Figures

Formulation

CYCS antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

CYCS antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CYCS antibody,CYC antibody,HCS antibody,THC4 antibody

Database links

Human UniProt/Swiss-Prot:P99999

Protein names

CYCS,CYC,HCS,THC4

Protein function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.; Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Protein sequence and domain

Belongs to the cytochrome c family.

Protein post-translational modifications

Binds 1 heme group per subunit.; Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.

Protein cellular localization

Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.

Background

Cytochrome c is a well conserved electron-transport protein and is part of the respiratory chain localized to mitochondrial intermembrane space (1). Upon apoptotic stimulation, cytochrome c released from mitochondria associates with procaspase-9 (47 kDa)/Apaf 1. This complex processes caspase-9 from inactive proenzyme to its active form (2). This event further triggers caspase-3 activation and eventually leads to apoptosis (3).

Research area

All research areas>Tumor Suppressor/Apoptosis>Cytochrome
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize CYCS antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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