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Rabbit polyclonal DACH1 antibody (A6895)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal DACH1 antibody.
Check alternative names for the antibodyExpand
DACH antibody|Dach1 antibody|DACH1_HUMAN antibody|dachshund homolog 1 (Drosophila) antibody|Dachshund homolog 1 antibody|Dachsund homolog 1 antibody|FLJ10138 antibody|OTTHUMP00000018494 antibody|Anti-DACH1 antibody [EPR2841Y] (ab77234)
SCBT cat No: sc-398706|sc-98563|
Rabbit polyclonal DACH1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human DACH1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 79kDa/Observed: Refer to figures
DACH1 antibody was tube-contained.
DACH1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).
|Protein tissue specificity|| |
Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.
|Protein sequence and domain|| |
The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.Belongs to the DACH/dachshund family.
|Protein cellular localization|| |
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene.
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|Product type|| |
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