Rabbit polyclonal DBI antibody (A5370)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DBI antibody (A5370)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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EP antibody, ACBP antibody, ACBD1 antibody, CCK-RP antibody
ACBD 1 antibody|ACBD1 antibody|ACBP antibody|ACBP_HUMAN antibody|Acyl CoA binding domain containing 1 antibody|Acyl CoA binding protein antibody|Acyl Coenzyme A binding domain containing 1 antibody|Acyl coenzyme A binding protein antibody|Acyl-CoA-binding protein antibody|CCK RP antibody|CCKRP antibody|Cholecystokinin releasing peptide trypsin sensitive antibody|DBI antibody|Diazepam-binding inhibitor antibody|Endozepine antibody|EP antibody|GABA receptor modulator antibody|MGC70414 antibody|Anti-Diazepam Binding Inhibitor antibody [27C9] (ab16806)

SCBT cat No: sc-376853|sc-30190|sc-23476|

Name

Rabbit polyclonal DBI antibody

Catalogue No.

A5370

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DBI

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 10kDa/Observed: Refer to Figures

Formulation

DBI antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DBI antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EP antibody, ACBP antibody, ACBD1 antibody, CCK-RP antibody

Database links

Human UniProt/Swiss-Prot:P07108

Protein names

EP, ACBP, ACBD1, CCK-RP

Protein function

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Protein tissue specificity

Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.

Protein sequence and domain

Belongs to the ACBP family.; Contains 1 ACB (acyl-CoA-binding) domain.

Protein cellular localization

Endoplasmic reticulum . Golgi apparatus . Note: Golgi localization is dependent on ligand binding .

Background

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.

Research area

All research areas>Signaling Intermediates>ACBP
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize DBI antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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