Rabbit polyclonal DCP2 antibody (A8282)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DCP2 antibody (A8282)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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NUDT20 antibody
DCP2 antibody|DCP2 decapping enzyme homolog (S. cerevisiae) antibody|DCP2, S. cerevisiae, homolog of antibody|DCP2_HUMAN antibody|decapping enzyme 2, S. cerevisiae, homolog of antibody|decapping enzyme homolog (S. cerevisiae) antibody|FLJ33245 antibody|hDpc antibody|m7GpppN-mRNA hydrolase antibody|mRNA decapping enzyme 2 antibody|mRNA-decapping enzyme 2 antibody|Nucleoside diphosphate-linked moiety X motif 20 antibody|nudix (nucleoside diphosphate linked moiety X)-type motif 20 antibody|Nudix motif 20 antibody|NUDT20 antibody|Anti-Dcp2 antibody (ab28658)

SCBT cat No: sc-368179|sc-133650|

Name

Rabbit polyclonal DCP2 antibody

Catalogue No.

A8282

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DCP2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 48kDa/Observed: Refer to figures

Formulation

DCP2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DCP2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NUDT20 antibody

Database links

Human UniProt/Swiss-Prot:Q8IU60

Protein names

NUDT20

Protein function

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs . Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5′-phosphorylated mRNA fragment and 7m-GDP . Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay . Plays a role in replication-dependent histone mRNA degradation . Has higher activity towards mRNAs that lack a poly(A) tail . Has no activity towards a cap structure lacking an RNA moiety . Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts .

Protein tissue specificity

Expressed in brain and testis. Not detected in heart (at protein level).

Protein sequence and domain

Belongs to the Nudix hydrolase family. DCP2 subfamily.; Contains 1 nudix hydrolase domain.

Protein post-translational modifications

Phosphorylated at ser-249 in a MTOR-dependent manner .

Protein cellular localization

Cytoplasm, P-body . Nucleus . Note: Predominantly cytoplasmic, in processing bodies (PB) . A minor amount is nuclear .

Background

The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5′ end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Note

AntibodyPlus can customize DCP2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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