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Rabbit polyclonal DCP2 antibody (A8282)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal DCP2 antibody.
Check alternative names for the antibodyExpand
DCP2 antibody|DCP2 decapping enzyme homolog (S. cerevisiae) antibody|DCP2, S. cerevisiae, homolog of antibody|DCP2_HUMAN antibody|decapping enzyme 2, S. cerevisiae, homolog of antibody|decapping enzyme homolog (S. cerevisiae) antibody|FLJ33245 antibody|hDpc antibody|m7GpppN-mRNA hydrolase antibody|mRNA decapping enzyme 2 antibody|mRNA-decapping enzyme 2 antibody|Nucleoside diphosphate-linked moiety X motif 20 antibody|nudix (nucleoside diphosphate linked moiety X)-type motif 20 antibody|Nudix motif 20 antibody|NUDT20 antibody|Anti-Dcp2 antibody (ab28658)
SCBT cat No: sc-368179|sc-133650|
Rabbit polyclonal DCP2 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human DCP2
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 48kDa/Observed: Refer to figures
DCP2 antibody was tube-contained.
DCP2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs . Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5′-phosphorylated mRNA fragment and 7m-GDP . Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay . Plays a role in replication-dependent histone mRNA degradation . Has higher activity towards mRNAs that lack a poly(A) tail . Has no activity towards a cap structure lacking an RNA moiety . Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts .
|Protein tissue specificity|| |
Expressed in brain and testis. Not detected in heart (at protein level).
|Protein sequence and domain|| |
Belongs to the Nudix hydrolase family. DCP2 subfamily.; Contains 1 nudix hydrolase domain.
|Protein post-translational modifications|| |
Phosphorylated at ser-249 in a MTOR-dependent manner .
|Protein cellular localization|| |
Cytoplasm, P-body . Nucleus . Note: Predominantly cytoplasmic, in processing bodies (PB) . A minor amount is nuclear .
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5′ end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
AntibodyPlus can customize DCP2 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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