Rabbit polyclonal DCTN1 antibody (A1783)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DCTN1 antibody (A1783)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DCTN1 antibody.

Alternative names:

Check alternative names for the antibody

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DAP-150 antibody, DP-150 antibody, HMN7B antibody, P135 antibody
150 kDa dynein associated polypeptide antibody|150 kDa dynein-associated polypeptide antibody|DAP 150 antibody|DAP-150 antibody|DAP150 antibody|DCTN 1 antibody|DCTN1 antibody|DCTN1_HUMAN antibody|DP 150 antibody|DP-150 antibody|DP150 antibody|Dynactin 1 (p150 Glued (Drosophila) homolog) antibody|Dynactin 1 (p150 glued homolog Drosophila) antibody|Dynactin 1 antibody|Dynactin subunit 1 antibody|Dynactin1 antibody|HMN7B antibody|p135 antibody|p150 Glued (Drosophila) homolog antibody|p150 glued antibody|p150 glued homolog antibody|p150(GLUED) DROSOPHILA HOMOLOG OF antibody|p150-glued antibody|p150glued antibody|Anti-DCTN1 antibody (ab11806)

SCBT cat No: sc-365274|sc-365054|sc-9801|sc-271166|sc-11363|sc-167697|sc-393389|

Name

Rabbit polyclonal DCTN1 antibody

Catalogue No.

A1783

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DCTN1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 142kDa/Observed: Refer to Figures

Formulation

DCTN1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DCTN1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DAP-150 antibody, DP-150 antibody, HMN7B antibody, P135 antibody

Database links

Human UniProt/Swiss-Prot:Q14203

Protein names

DAP-150, DP-150, HMN7B, P135

Protein function

Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.

Protein tissue specificity

Brain.

Protein sequence and domain

Belongs to the dynactin 150 kDa subunit family.; Contains 1 CAP-Gly domain.

Protein post-translational modifications

Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.; Phosphorylation by SLK at Thr-145, Thr-146 and Thr-147 targets DCTN1 to the centrosome. It is uncertain if SLK phosphorylates all three threonines or one or two of them.

Protein cellular localization

Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Note: Colocalizes with microtubules . Localization at centrosome is regulated by SLK-dependent phosphorylation .

Background

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]

Note

AntibodyPlus can customize DCTN1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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