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Rabbit polyclonal DDR2 antibody (A10060)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal DDR2 antibody.
Check alternative names for the antibodyExpand
CD167 antigen-like family member B antibody|Tyrosine protein kinase TYRO 10 antibody|Tyrosine protein kinase TYRO10 antibody|Tyrosine-protein kinase TYRO10 antibody|Tyrosylprotein kinase antibody|Anti-DDR2 antibody (ab76967)
SCBT cat No: sc-81707|sc-8989|sc-7555|
Rabbit polyclonal DDR2 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human DDR2
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 97kDa/Observed: Refer to figures
DDR2 antibody was tube-contained.
DDR2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
|Protein tissue specificity|| |
Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.; Contains 1 F5/8 type C domain.; Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
N-glycosylated.; Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and subsequent autophosphorylation on additional tyrosine residues.
|Protein cellular localization|| |
Cell membrane ; Single-pass type I membrane protein .
AntibodyPlus can customize DDR2 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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