Rabbit polyclonal DDX11 antibody (A7666)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DDX11 antibody (A7666)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CHL1 antibody, KRG2 antibody, WABS antibody, CHLR1 antibody
CHL1 antibody|CHL1-like helicase homolog antibody|CHLR1 antibody|Ddx11 antibody|DDX11_HUMAN antibody|DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 antibody|DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 antibody|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) antibody|DEAD/H box antibody|DEAD/H box protein 11 antibody|hCHLR1 antibody|Keratinocyte growth factor regulated gene 2 protein antibody|Keratinocyte growth factor-regulated gene 2 protein antibody|KRG 2 antibody|KRG-2 antibody|KRG2 antibody|MGC133249 antibody|MGC9335 antibody|OTTHUMP00000238778 antibody|OTTHUMP00000238780 antibody|OTTHUMP00000238784 antibody|OTTHUMP00000238785 antibody|Probable ATP dependent RNA helicase DDX11 antibody|Probable ATP-dependent RNA helicase DDX11 antibody|WABS antibody|Anti-DDX11 antibody – C-terminal (ab170473)

SCBT cat No: sc-515166|sc-271711|sc-515168|sc-271700|sc-68855|

Name

Rabbit polyclonal DDX11 antibody

Catalogue No.

A7666

Reactivity

Human

Immunogen

Recombinant protein of human DDX11

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 108kDa/Observed: Refer to figures

Formulation

DDX11 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DDX11 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CHL1 antibody, KRG2 antibody, WABS antibody, CHLR1 antibody

Database links

Human UniProt/Swiss-Prot:Q96FC9

Protein names

CHL1, KRG2, WABS, CHLR1

Protein function

DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5′ to 3′ direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5′-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex activities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Required for recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genome maintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and the prevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- and double-stranded DNA.

Protein tissue specificity

Highly expressed in spleen, B-cells, thymus, testis, ovary, small intestine, and pancreas. Very low expression seen in the brain. Expressed in dividing cells and/or cells undergoing high levels of recombination. No expression is seen in cells signaled to terminally differentiate. Expressed in keratinocyte growth factor-stimulated cells but not in serum, EGF and IL1-beta-treated keratinocytes.

Protein sequence and domain

Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.; Contains 1 helicase ATP-binding domain.

Protein cellular localization

Nucleus . Nucleus, nucleolus . Note: During the early stages of mitosis, localizes to condensed chromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle poles throughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase). Co-localizes with bovine papillomavirus type 1 regulatory protein E2 at early stages of mitosis.

Background

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Research area

All research areas>Transcription Regulators>DDX
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize DDX11 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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