Rabbit polyclonal DDX20 antibody (A5817)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal DDX20 antibody (A5817)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal DDX20 antibody.

Alternative names:

Check alternative names for the antibody

Expand

DP103 antibody, GEMIN3 antibody
Component of gems 3 antibody|DDX 20 antibody|ddx20 antibody|DDX20_HUMAN antibody|DEAD (Asp Glu Ala Asp) box polypeptide 20 antibody|DEAD box protein 20 antibody|DEAD box protein DP 103 antibody|DEAD box protein DP103 antibody|DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 103kD antibody|DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 antibody|DEAD/H BOX 20 antibody|DKFZP434H052 antibody|DP 103 antibody|DP103 antibody|Gemin-3 antibody|Gemin3 antibody|Probable ATP dependent RNA helicase DDX20 antibody|Probable ATP-dependent RNA helicase ddx20 antibody|SMN interacting protein antibody|Anti-Gemin 3 antibody [12H12] (ab10305)

SCBT cat No: sc-57007|sc-135919|sc-374373|sc-271853|sc-50405|

Name

Rabbit polyclonal DDX20 antibody

Catalogue No.

A5817

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human DDX20

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 92kDa/Observed: Refer to Figures

Formulation

DDX20 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

DDX20 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DP103 antibody, GEMIN3 antibody

Database links

Human UniProt/Swiss-Prot:Q9UHI6

Protein names

DP103, GEMIN3

Protein function

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

Belongs to the DEAD box helicase family. DDX20 subfamily.; Contains 1 helicase ATP-binding domain.; Contains 1 helicase C-terminal domain.

Protein cellular localization

Cytoplasm. Nucleus, gem. Note: Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).

Background

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.

Research area

All research areas>Neurobiology>Gemin
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize DDX20 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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