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Rabbit polyclonal DDX39B antibody (A8356)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:100 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal DDX39B antibody.
Check alternative names for the antibodyExpand
BAT1 antibody, UAP56 antibody, D6S81E antibody
0610030D10Rik antibody|4F2-LC6 antibody|56 kDa U2AF65-associated protein antibody|AI428441 antibody|ATP-dependent RNA helicase p47 antibody|B(0,+)-type amino acid transporter 1 antibody|BAT1 antibody|Bat1a antibody|D17H6S81E antibody|D17H6S81E-1 antibody|D6S81E antibody|D6S81Eh antibody|DDX39B antibody|DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B antibody|DEAD box protein UAP56 antibody|DX39B_HUMAN antibody|EC 3.6.1.- antibody|Glycoprotein-associated amino acid transporter b0,+AT1 antibody|HLA-B-associated transcript 1 protein antibody|HLA-B-associated transcript 1A antibody|HLA-B-associated transcript-1 antibody|MGC127051 antibody|MGC19235 antibody|MGC38799 antibody|nuclear RNA helicase (DEAD family) antibody|OTTHUMP00000029229 antibody|OTTHUMP00000165889 antibody|OTTHUMP00000165890 antibody|p47 antibody|Solute carrier family 7 member 9 antibody|Spliceosome RNA helicase BAT1 antibody|Spliceosome RNA helicase DDX39B antibody|U2AF65-associayed protein, 56-KD antibody|UAP56 antibody|Anti-UAP56 antibody (ab47955)
SCBT cat No: sc-68342|sc-271395|
Rabbit polyclonal DDX39B antibody
|Catalogue No.|| |
Recombinant protein of human DDX39B
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 49kDa/Observed: Refer to figures
DDX39B antibody was tube-contained.
DDX39B antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
BAT1 antibody, UAP56 antibody, D6S81E antibody
|Database links|| |
|Protein names|| |
BAT1, UAP56, D6S81E
|Protein function|| |
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5′ end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi’s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.; Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5′ or 3′ overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect.
|Protein sequence and domain|| |
The helicase C-terminal domain mediates interaction with ALYREF/THOC4.Belongs to the DEAD box helicase family. DECD subfamily.; Contains 1 helicase ATP-binding domain.; Contains 1 helicase C-terminal domain.
|Protein cellular localization|| |
Nucleus. Nucleus speckle. Cytoplasm. Note: Can translocate to the cytoplasm in the presence of MX1. TREX complex assembly seems to occur in regions surrounding nuclear speckles known as perispeckles.
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene.
AntibodyPlus can customize DDX39B antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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